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Effects on infiltration Anesthesia induced by different concentrations of local anesthesics and epinephrine

不同浓度局麻药和肾上腺素对浸润麻醉的影响

基本信息

批准号：
08457558
负责人：
AMEMIYA Yoshihiro
金额：
$ 4.1万
依托单位：
Tsurumi University School of Dental Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457558/
关键词：
lidocaine epinephrine SEP propitocaine local anesthetic effect rat 局所麻酔薬エピネフリン濃度

项目摘要

The most widely used dental local anesthetic in Japan contains a relatively high concentration of epinephrine.This concentration is thought to be high enough to cause cardiovascular changes, especially in the elderly or in patients with cardiovascular diseases.This study was designed to examine the effects on infiltration anesthesia induced by differentconcentrations of lidocaine and epinephrine by using SEP.Rats were anesthetized with thiamylal sodium injected peritoneally. A bipolar stimulative electrode was inserted into the pulp of the upper incisor. The pulp was stimulated electrically, and SEP was recorded from the contralateral surface of the skull . Six local anesthetics were used ; 2% lidocaine (Group 2L), 2% lidocaine containing 1 : 200,000 epinephrine (Group 2L20), 1 : 160,000 epinephrine (Group 2L16), or 1 : 80,000 epinephrine (Group 2L8), 3% lidocaine containing 1 : 160,000 epinephrine (Group 3L16), and 3% prilocaine containing 0.03 IU/ml felypressin (Group PF). 50 mu 1 of … More each combination were injectedinto the palate paraperiosteally. The amplitude of the primary SEP responses was measured, and the hanges were analyzed statistically.In all six groups, a reduction in % amplitude was found from immediately after the injection. The duration in order of their length were as follows : 2L8 (]SY.di-substituted left.[) 2L20(]SY.di-substituted left.[) PF (]SY.di-substituted left.[) 2L16(]SY.di-substituted left.[) 3L16(]SY.di-substituted left.[) 2L.The reductions was greatest in Group 3L16, followed by 2L8, and then they were similar in Groups 2L, 2L20, 2L16, and PF.The reductions in Group 3L1 6 were significantly greater than Group 2L8 until 30 min, and they were recovered rapidly after then. No significant differences were seen among Groups 2L, 2L20, 2L16, and PF.The maximum reductions were seen at 8-10 min in all groups. The value of the maximum suppression of Group 2L was 51.1 %. When this value was used as the standard of comparison (2L = 1), the potencies were as follows : 2L : 2L20 : 2L16 : 2L8 : 3L16 : PF were 1 : 1 : 1 : 1.5 : 1.9 : 1.3.The results suggest that, if the concentration of epinephrine is decreased, the concentration of local anesthetic should be increased and that 3L16 can possibly be as effective for dental local anesthesia as 2L8, as long as the dental procedure is completed within 30 min. Less

在日本使用最广泛的牙科局部麻醉药中含有较高浓度的肾上腺素，这种浓度被认为足以引起心血管疾病，特别是老年人或心血管疾病患者。本研究旨在用SEP检查不同浓度的利多卡因和肾上腺素对浸润麻醉的影响。将双极刺激电极插入上切牙的牙髓中。电刺激牙髓，从颅骨的对侧表面记录SEP。使用了6种局部麻醉剂; 2%利多卡因（2L组），含1：200，000肾上腺素的2%利多卡因（组2L 20），1：160，000肾上腺素（组2L 16），或1：80，000肾上腺素含1：160，000肾上腺素的3%利多卡因（3L 16组）和含0.03 IU/ml苯来加压素的3%丙胺卡因（PF组）。50亩 ...更多信息将每种组合注射到腭骨膜旁。结果发现，注射后即刻，6组大鼠的体感诱发电位波幅（%）均降低，而注射后即刻，各组大鼠的体感诱发电位波幅（%）均降低。其持续时间按其长度顺序如下：2L 8（）SY.双取代左。[）2L20（]SY. [）PF（]SY.双取代左。[）2L16（]SY. [）3L16（]SY.（）2L：3L 16组下降幅度最大，2L 8组次之，2L、2L 20、2L 16、PF组相似，3L 16组下降幅度在30 min前显著大于2L 8组，30 min后迅速恢复。在2L、2L 20、2L 16和PF组中未观察到显著差异。在所有组中，在8-10 min时观察到最大降低。2L组的最大抑制值为51.1%。当该值用作比较标准品（2L = 1）时，效价如下：2L：2L 20：2L 16：2L 8：3L 16：PF为1：1：1：1.5：1.9：1.3.结果表明，如果肾上腺素浓度降低，应增加局部麻醉剂的浓度，只要在30分钟内完成牙科手术，3L 16可能与2L 8一样有效。