Arterial blood pressure responses to mild exercise, maximum aerobic power, and reflexes of baroreceptors in healthy young persons with genetic disposition of hypertension

具有高血压遗传倾向的健康年轻人对轻度运动、最大有氧功率和压力感受器反射的动脉血压反应

• 批准号: 02451091
• 负责人: GUNJI Atsuaki
• 金额: $ 3.01万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02451091/
• 关键词: genetic disposition of hypertension; inhibitory effect on regulating sympathetic; low-baroreceptor; high-baroreceptor; baroreceptor reflex; lower body negative pressure; neck suction; maximum aerobic power; 高血圧遺伝子素因; 心肺圧受容器; 頸動脈洞圧受容器; 起立性循環調節耐容

To know workers and/or predictors of hypertension before its' onset in normal young persons with the genetic disposition, the present study has investigated relations between arterial blood pressure responses to mild exercise, maximum aerobic power, and reflexes of high- and low-baroreceptors in human subjects.In 1990, a main work was on establishing indirect (bloodless) methods how to make separately and simultaneously stimulating high-baroreceptors in the carotid sinus and low- baroreceptors in the cardio-pulmonary part. Another was how to decide characteristics of subjects selected. The practical studies have been performed according to following themes ; 1. as methodological studies, A. developing a system stimulating the high-baroreceptors, B. basal investigation determining pressure loads on the high- and low-baroreceptors, C. realm selecting subjects, and 2. as knowing blood pressure responses to upright exercise, A. blood pressure responses to exercise increasing with step-by-s … More tep loads in healthy young persons with the disposition, B. effects of physical training on blood pressure responses to rest and exercise, C. effects of life styles on blood pressure responses to rest and exercise in middle aged persons with the disposition. Depending on the results in the studies, it has been concluded that the upper-limit of lower body negative pressure load to stimulate baroreceptors in cardio-pulumonary part is a -40mmHg, upper-limit of neck suction pressure to stimulate baroreceptors in carotid sinus is a -50mmHg, a load in mild upright exercise is a 50watts, and the subjects would exclude any persons who had higher % body fat or higher maximum aerobic power than the levels in normal healthy persons even though they held the genetic desposition of hypertension.In 1991, followed in the conclusions given by the previous studies, two studies have been performed ; 1. changes in awakening blood pressure and heart rate during 10 days bed-rest in normal healthy young persons with genetic disposition with hypertension, and 2. arterial blood pressure responses during mild upright exercise and sensibilities of high- and low-baroreceptors reflexes in the young persons. In the studies, it has been found that in normal healthy persons with the disposition the blood pressure response to mild upright exercise is higher, and the inhibitory effect of low-baroreceptors in the cardio-pulmonary part on regulating sympathetic nervous activity is stronger as compared with young persons without the disposition, but the the effect of high-baroreceptors in the carotid sinus is similar. Less

为了了解具有遗传倾向的正常年轻人高血压发病前的工作人员和/或预测因素，本研究调查了人类受试者中动脉血压对轻度运动、最大有氧能力和高、低压力感受器反射的反应之间的关系。1990年的主要工作是建立间接（无血）方法，分别同时刺激颈动脉窦内的高压力感受器和心肺部的低压力感受器。另一个问题是如何确定被选对象的特征。根据以下主题进行了实践研究；1. 作为方法学研究，a .开发刺激高压力感受器的系统，B.确定高压力感受器和低压力感受器压力负荷的基础研究，C.领域选择受试者，以及2。在了解直立运动对血压的反应时，A.运动对血压的反应随步量的增加而增加，B.体能训练对血压对休息和运动反应的影响，C.生活方式对血压对休息和运动反应的影响。根据研究结果得出：刺激心肺部压力感受器的下体负压负荷上限为-40mmHg，刺激颈动脉窦压力感受器的颈部吸压负荷上限为-50mmHg，轻度直立运动负荷为50watts。受试者将排除任何体脂率或最大有氧能力高于正常健康人的人，即使他们有高血压的遗传沉积。1991年，在前几项研究得出结论之后，又进行了两项研究；1. 2.有高血压遗传倾向的正常健康青年10天卧床期间觉醒血压和心率的变化。年轻人轻度直立运动时的动脉血压反应和高、低压力感受器反射的敏感性。在研究中发现，有性格的正常健康人对轻度直立运动的血压反应高于无性格的年轻人，且心肺部位的低压力感受器对交感神经活动的调节抑制作用强于无性格的年轻人，但颈动脉窦的高压力感受器的作用相似。少