Elucidation of the buildup mechanism of eumelanin particles and specific isolation of intermediates

阐明真黑色素颗粒的形成机制和中间体的特异性分离

• 批准号: 429844944
• 负责人: Professor Dr. Klaus Huber
• 金额: --
• 依托单位: Arbeitskreis Strukturbildung in weicher Materie, Lichtstreuung und Kleinwinkelstreuung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/429844944?language=en
• 关键词: Elucidation; buildup; mechanism; eumelanin; particles

Eumelanin is a biological pigment with extraordinary materials properties like radiation protection, radical scavenging, paramagnetism, controlled drug release, and hybrid electrical conductivity. The buildup of melanin pigments includes a molecular and a supramolecular aspect. The molecular aspect is quite well understood. The supramolecular buildup to the final particles however, is mostly unknown. This is to a great extent due to the specific challenges, connected to this system, as the complete synthesis consists of three major, overlapping aspects: Monomer synthesis, polymerization, and supramolecular particle formation. Moreover, each aspect consists of several reaction steps.First results on the particle formation have been gained in own preliminary research. It became clear that the buildup consists of four distinct, hierarchical levels. The specific particle types are quite monodisperse and are distinguishable by size variations of one order of magnitude each. Based on this, a mechanism for the complete buildup process was proposed, which is included in this proposal as working hypothesis.The aim of this project is a complete elucidation of the supramolecular buildup of eumelanin. Additionally, specific isolation of every particle type within this buildup in applicable amounts is aspired. This is realized by a three-fold guiding principle consisting of (i) a tailor-made reactor for parameter control and in situ analytics, (ii) time resolved scattering methods, and (iii) microscopy.First, influences of the various parameters and precursors on the supramolecular buildup will be investigated with this approach, to gain control over the process. This shall allow for acceleration, deceleration, or inhibition of each step within the buildup. Moreover, the underlying mechanisms of each buildup-step will be elucidated completely, to gain a deep understanding of the entire process. The combined results will finally enable stable isolation of gram-amounts of every particle type for future application in innovative materials.

真黑素是一种生物色素，具有非凡的材料特性，如辐射防护、自由基清除、顺磁性、受控药物释放和混合导电性。黑色素的形成包括分子和超分子方面。分子方面已经很好理解了。然而，最终颗粒的超分子积累大多是未知的。这在很大程度上是由于与该系统相关的具体挑战，因为完整的合成由三个主要的、重叠的方面组成：单体合成、聚合和超分子颗粒形成。此外，每个方面都由几个反应步骤组成。在自己的初步研究中，已经获得了关于颗粒形成的初步结果。很明显，该构建由四个不同的层次结构组成。特定的颗粒类型是相当单分散的，并且可以通过每个颗粒的一个数量级的尺寸变化来区分。在此基础上，提出了完整的构建过程的机制，该机制作为工作假设包含在本提案中。该项目的目的是完整阐明真黑素的超分子构建。此外，期望以适当的量具体分离该堆积物中的每种颗粒类型。这是通过三重指导原则实现的，包括（i）用于参数控制和原位分析的定制反应器，（ii）时间分辨散射方法，以及（iii）显微镜。首先，将用这种方法研究各种参数和前体对超分子堆积的影响，以获得对过程的控制。这应允许加速、减速或抑制构建中的每个步骤。此外，每个构建步骤的基本机制将被完全阐明，以深入了解整个过程。综合结果最终将能够稳定分离克量的每种颗粒类型，以供未来在创新材料中的应用。