Identification at Parallel Distributed Processing in the Plasticity of Neural Networks by Using on Optical Recording System

光记录系统中神经网络可塑性并行分布式处理的识别

• 批准号: 02452169
• 负责人: TSUKADA Minoru
• 金额: $ 4.22万
• 依托单位: Tamagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02452169/
• 关键词: Optical Recording; Temporal Pattern; LTP(long-term potentiation); Learning and Memory; Hippocampus; Hippocampal-cortical memory system; 可塑性神経回路; 並列情報処理; オプティカルレコーディング; 時間パターン学習アルゴリズム; 海馬-皮質記憶システム; オプティカルレコ-ディング; 学習アルゴリズム

1. We developed a 144-channels optical recording system, by which we succeeded in recording multi-units activities of hippocampal neurons. By using the method, the different LTP of CA1 neurons induced by the temporal pattern stimuli were identified.2. We find that the potentiation depend not only on the frequency of the stimulus, but on the degree of correlation between successive intervals, even when the average frequency of the stimulus set is held constant. This suggests that detailed temporal properties of the stimulus are important factors for inducing LTP, and hence could play a crucial role in learning and memory phenomenan.3. We proposed a mathematical model for the induction of LTP in the CA1 region of the hippocampus based on the physiological data obtained above. The model learning rule is essentially Hebbian in nature in the sense that the amount of the LTP induced increases with frequency of synaptic activation, but it also has a sensitivity on the correlation between inter-stimulus intervals of applied stimulus chain.4. Based on the physiological evidence, we proposed a hypothesis on how association and dissociation of event memories are made in the hippocampal-cortical memory system. It is postulated that association /dissociation of memory is carried out by indexing the representations of events (memory contents) with temporal codes.

1. 我们研制了144通道光学记录系统，成功地记录了海马神经元的多单元活动。利用该方法鉴定了CA1神经元在时间模式刺激下的不同LTP。我们发现，即使在刺激集的平均频率保持不变的情况下，增强不仅取决于刺激的频率，而且取决于连续间隔之间的相关程度。这表明刺激的详细时间特性是诱发LTP的重要因素，因此可能在学习和记忆现象中起重要作用。基于上述生理数据，我们提出了海马CA1区LTP诱导的数学模型。模型学习规则本质上是Hebbian性质的，即LTP的诱导量随着突触激活频率的增加而增加，但它对应用刺激链的刺激间隔之间的相关性也有敏感性。基于生理证据，我们提出了事件记忆的关联和分离是如何在海马-皮层记忆系统中形成的假说。据推测，记忆的关联/分离是通过索引事件（记忆内容）的表征与时间代码来进行的。

项目成果

M.Terasawa and M.Tsukada: "Temporal pattern discrimination in swetch off learning studied by electrical stimulation in PAG of rad." World Congress on Medical Physics and Biomed.Eng.29 (1991)

M.Terasawa 和 M.Tsukada：“通过 rad 的 PAG 中的电刺激研究 swetch off 学习中的时间模式辨别。”

M.Tsukada,T.Aihara,M.Mizuno,H.Kato and K.Ito: "Temporal pattern sensitivity of long-term potentiation in hippocampal CAl neurons." To be published in Biological Cybernetics. (1993)

M.Tsukada、T.Aihara、M.Mizuno、H.Kato 和 K.Ito：“海马 CA1 神经元长期增强的时间模式敏感性。”

T.Aihara,M.Tsukada,M.Crair,S.Shinomoto: "The stimulus dependent induction of long-term potentiation in the CAl area of the hippocampus I:Experiment." To be published in Biological Cybernetics. (1993)

T.Aihara、M.Tsukada、M.Crair、S.Shinomoto：“海马 CA1 区长期增强的刺激依赖性诱导 I：实验”。

M.Tsukada: "Temporal pattern cording in the hippocampal-cortical memory system." International symposium on neural information processing. 184-187 (1992)

M.Tsukada：“海马皮质记忆系统中的时间模式编码。”

S.Shinomoto, M.Crair, M.Tsukada, T.Aihara: "The stimulus dependent induction of long-term potentiation in the CA1 area of the hippocampus II:Mathematical model." Biological Cybernetics.(1993)

S.Shinomoto、M.Crair、M.Tsukada、T.Aihara：“海马 CA1 区长期增强的刺激依赖性诱导 II：数学模型。”