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An experimental investigation and Dynamic model of learning & memory

实验研究和学习的动态模型

基本信息

批准号：
12210017
负责人：
TSUKADA Minoru
金额：
$ 98.24万
依托单位：
Tamagawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2004
项目状态：
已结题

项目摘要

Through theory and experimental evidence, the expression of information (coding) involved in the encoding and processing of memory in the hippocampal cortical system has become evident. Specifically, Tsukada et al. have shown that the spatiotemporal learning rule is effective in temporarily storing a spatiotemporal pattern in the synaptic weight space of the CAl circuit in the hippocampal neural network (Tsukada et al.,1996, 1998; Tsukada,2004; Tsukada et al., 2005; Aihara et al.2005; Tsukada and Pan,2005).In the auditory cortex, it has been revealed that a timing dependent gating (timing window) exists between sensory information and hippocampal information (Yamamoto et al., 1999, Miyazaki et al., 2005). The fact that inhibitory and excitatory modifications are generated in response to the activity of the auditory area which is regulated by the structure of activity in the hippocampal CAlarea, signifies that the processing of complex information is possible in regards to information f … More rom the hippocampus which is encoded in the cerebral cortex auditory area. In addition, we were successful in measuring the plastic responses of the auditory cortex before and after the learning of fear conditioning with sound and electric shock by using the voltage sensitive optical recording method.With a conditioned frequency, the responsive field enlarged, while with unconditioned frequencies, there was no significant change in the responsive field (Miyazaki et al., 2005). Based upon experimental results, the model was constructed which resulted in the following. When context information was inputted from the hippocampus, along with an enlargement of the receptive field the encoding and processing time improved considerably, and the correct rate of the memory pattern also increased (Tsukada and Pan, 2005). The enlargement of the receptive field explains why the significant increase in the response area in the auditory cortex was seen in experimentation when the CS tone was presented. Less

通过理论和实验证据，海马皮质系统中参与记忆编码和加工的信息（编码）表达已变得明显。具体地，Tsukada等人已经表明，时空学习规则在海马神经网络中的CA 1回路的突触权重空间中临时存储时空模式方面是有效的（Tsukada等人，1996，1998; Tsukada，2004; Tsukada等人，二○ ○五年; Aihara等人，2005; Tsukada和Pan，2005）。在听觉皮层中，已经揭示了在感觉信息和海马信息之间存在时间依赖性门控（时间窗）（Yamamoto等人，1999年，宫崎等人，2005年）。听觉区的活动受海马CAlarea的活动结构的调节，在听觉区的活动中产生抑制性和兴奋性的改变，这一事实表明，复杂信息的处理是可能的。 ...更多信息来自海马体，海马体编码在大脑皮层听觉区。此外，我们还成功地用电压敏感光学记录方法测量了听觉皮层在学习声音和电击恐惧条件反射之前和之后的可塑性反应。在条件频率下，反应场扩大，而在非条件频率下，反应场没有显著变化（宫崎et al.，2005年）。基于实验结果，构建了模型，其结果如下。当从海马体输入上下文信息时，沿着感受野的扩大，编码和处理时间显著改善，记忆模式的正确率也增加（Tsukada and Pan，2005）。感受野的扩大解释了为什么在实验中看到CS音时听觉皮层反应区的显着增加。少