An experimental investigation and Dynamic model of learning & memory

实验研究和学习的动态模型

基本信息

批准号：
12210017
负责人：
TSUKADA Minoru
金额：
$ 98.24万
依托单位：
Tamagawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2004
项目状态：
已结题

项目摘要

Through theory and experimental evidence, the expression of information (coding) involved in the encoding and processing of memory in the hippocampal cortical system has become evident. Specifically, Tsukada et al. have shown that the spatiotemporal learning rule is effective in temporarily storing a spatiotemporal pattern in the synaptic weight space of the CAl circuit in the hippocampal neural network (Tsukada et al.,1996, 1998; Tsukada,2004; Tsukada et al., 2005; Aihara et al.2005; Tsukada and Pan,2005).In the auditory cortex, it has been revealed that a timing dependent gating (timing window) exists between sensory information and hippocampal information (Yamamoto et al., 1999, Miyazaki et al., 2005). The fact that inhibitory and excitatory modifications are generated in response to the activity of the auditory area which is regulated by the structure of activity in the hippocampal CAlarea, signifies that the processing of complex information is possible in regards to information f … More rom the hippocampus which is encoded in the cerebral cortex auditory area. In addition, we were successful in measuring the plastic responses of the auditory cortex before and after the learning of fear conditioning with sound and electric shock by using the voltage sensitive optical recording method.With a conditioned frequency, the responsive field enlarged, while with unconditioned frequencies, there was no significant change in the responsive field (Miyazaki et al., 2005). Based upon experimental results, the model was constructed which resulted in the following. When context information was inputted from the hippocampus, along with an enlargement of the receptive field the encoding and processing time improved considerably, and the correct rate of the memory pattern also increased (Tsukada and Pan, 2005). The enlargement of the receptive field explains why the significant increase in the response area in the auditory cortex was seen in experimentation when the CS tone was presented. Less

通过理论和实验证据，已经证明了在海马皮质系统中编码和处理记忆的信息（编码）的表达已得到证明。具体而言，Tsukada等人。已经表明，时空学习规则在临时存储中有效地在海马神经网络中Cal电路突触重量空间中的时空模式有效（Tsukada等，1996，1998; Tsukada; Tsukada，2004; Tsukada et lud.2005; aihara et al。感觉信息和海马信息之间存在一个依赖于时机的析导（时机窗口）（Yamamoto等，1999； Miyazaki等，2005）。抑制性和兴奋的修改产生的事实是，通过在更复杂的信息中进行了更为复杂的信息，这一事实是，抑制和兴奋的修改是响应于听觉区域的活性而进行的，这是高显着的，即高显着的……，显着的过程，显着地位，是显着的。在大脑皮层听觉区域编码的海马。此外，我们成功地测量了通过使用电压敏感的光学记录方法来学习通过声音和电击的恐惧调节之前和之后的听觉皮层的塑性反应。随着条件频率的增加，响应频率的增加，而无条件的频率却没有响应性较大的响应场（Miyyazaki et al。，2005年）。基于实验结果，构建了该模型，从而导致以下结果。当从海马中输入上下文信息，以及接收场的扩展，编码和处理时间会得到保守的改善，并且记忆模式的正确速率也会增加（Tsukada和Pan，2005年）。当出现CS张力时，在实验中可以看到听觉皮层中响应区域的显着增加。较少的