Mechnism of anti-atherogenic action of Eicosapentaenoic acid(EPA).

1)用纯化的EPA-E喂养大鼠的富含EPA的巨噬细胞中，胆固醇积聚对泡沫细胞形成的抑制作用显著降低。此外，在富含EPA的大鼠松果体巨噬细胞中，乙酰化低密度脂蛋白和PDGF的受体数量减少。2)抑制富含EPA的兔低密度脂蛋白的氧化修饰。用纯化的EPA-E喂养的兔所获得的富含EPA的低密度脂蛋白对钙催化的氧化修饰的敏感性较低。3)研究EPA对富含EPA的细胞的影响。EPA可抑制富含EPA的培养的大鼠血管平滑肌细胞的增殖。DHA也有类似的作用，但比EPA小。4)对富含EPA的大鼠血管平滑肌细胞产生PGI_2的影响。富含EPA的大鼠血管平滑肌细胞PGI2合成增加。这很可能是由来自EPA的过氧化脂质刺激环氧合酶活性来解释的。

1)Inhibition of foam cell formation by EPA Accumulation of cholesterol was sigunificantly decreased in EPA-rich peritoneal macrophages obtanined from rats fed with purified EPA-E. In addition receptor numbers of acetylated LDL and PDGF production were decreased in EPA-rich rat pineal macrophages. 2)Suppresion of oxidative modification of EPA-rich rabbit LDL. EPA-rich LDL obtained from rabbits fed with purified EPA-E showed a lesser susceptibility to Ca^<++>-catalysed oxidative modification. 3)Study of the effect of EPA on cells enriched with EPA. EPA suppressed proliferation of cultured rat vascular smooth muscle cell enriched with EPA. DHA had a similar effect, but lesser than EPA. 4)Effect of PGI_2 production in EPA-rich rat vascular smooth muscle cells. Enhanced PGI_2 synthesis was noted in EPA-enriched rat vascular smooth muscle cells. This could be most likely explained by stimulation of cyclooxygenase activity by lipid peroxides derived from EPA.