The immune-metabolic basis of the DEL-1/αvβ3 integrin-dependent induction of resolving macrophages in the resolution of inflammatory arthritis (C07*)

DEL-1/αvβ3 整合素依赖性诱导巨噬细胞在炎症关节炎消退中的免疫代谢基础 (C07*)

• 批准号: 430193679
• 金额: --
• 依托单位: Institut für Klinische Chemie und Laboratoriumsmedizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/430193679?language=en
• 关键词: immune; metabolic; basis; DEL; integrin

The project (Chavakis) is a new project, which builds on very recent findings on the molecular nature of the pro-resolving effect of efferocytosis- the uptake of apoptotic neutrophils by macrophages. It is based on a new pathway in resolution of inflammation: The DEL-1/v3 integrin-dependent efferocytosis of apoptotic neutrophils by macrophages promotes the emergence of a pro-resolving macrophage phenotype. The project aims at understanding the cellular metabolic basis of the DEL-1/v3 integrin-dependent induction of pro-resolving macrophages in the context of resolution of inflammatory arthritis. The project additionally brings cell metabolism expertise.

这个项目（Chavakis）是一个新项目，它建立在最近的发现上，即巨噬细胞摄取凋亡中性粒细胞的促溶作用的分子性质。它基于炎症解决的新途径：巨噬细胞对凋亡中性粒细胞的DEL-1/v3整合素依赖性efferocytosis促进了巨噬细胞表型的出现。该项目旨在了解DEL-1/v3整合素依赖性诱导促溶解巨噬细胞在炎性关节炎消退过程中的细胞代谢基础。该项目还带来了细胞代谢专业知识。