The immune-metabolic basis of the DEL-1/αvβ3 integrin-dependent induction of resolving macrophages in the resolution of inflammatory arthritis (C07*)

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The project (Chavakis) is a new project, which builds on very recent findings on the molecular nature of the pro-resolving effect of efferocytosis- the uptake of apoptotic neutrophils by macrophages. It is based on a new pathway in resolution of inflammation: The DEL-1/v3 integrin-dependent efferocytosis of apoptotic neutrophils by macrophages promotes the emergence of a pro-resolving macrophage phenotype. The project aims at understanding the cellular metabolic basis of the DEL-1/v3 integrin-dependent induction of pro-resolving macrophages in the context of resolution of inflammatory arthritis. The project additionally brings cell metabolism expertise.