BASIC STUDY ON TRADITIONAL MEDICINES HAVING SEDATIVE EFFECT FOR SEARCH OF NEUROTROPIC DRUG-MATERIAL

对南亚、南美洲常用的传统药材和药用植物进行了药理活性测定。从一些具有活性的中生植物中，通过活性引导程序分离出这些成分。日中药材龙牙菜和羌活的有效成分分别鉴定为ent-pimara-8(14)、15-dien-19-oic acid和ent-kaur-16-en-19-occ酸和notopterol。对这些化合物和当归中的蛇床子素进行了研究，探讨了它们之间的药理差异。婆罗洲药用植物少花大花蛇和大黄鱼的镇痛活性成分为吲哚生物碱，如冠桂碱、沃康因等，具有降温作用，但对运动活动无明显影响。秘鲁药用植物藜草和三叶草的镇静和止痛成分分别为蛔虫醇和Acteoside。通过对相关化合物的镇痛活性的比较，获得了有关Acteoside活性结构的信息，为一些具有镇静作用的传统药物和药用植物的药效提供了化学和药理基础。

pharmacological assay of traditional medicines and medicinal plants which have been used as narvine, analgesia, anxiolytic in South Asia and South America was done. From some midicinal plants showing activity, the principles were isolated by activity-guided procedure. The active compounds were furthermore tested for the other pharmacological effects to clarify their pharmacological properties.The active principles of Aralia cordata and Notopterygium incisum, Japanese-Chinese medicines, were identified as ent-pimara-8(14), 15-dien-19-oic acid and ent-kaur-16-en-19-oic acid and notopterol, respectively. These compounds and osthol from Angelica pubescens were examined to discuss for their pharmacological differences. Tabernaemontana pauciflora and T.pandacaqui, Bornean medicinal plants gave indole-alkaloids such as coronaridine, voacangine as analgesic principles which showed hypothermic effect but no effect on locomotor activity. The sedative and analgesic components of Peruvian medicinal plants, Chenopodium ambrosioides and Lipia triphylla were found to be ascaridole and acteoside, respectively. The information on the active structure of acteoside was also obtained by comparison of the analgesic activity of the related compounds.This investigation resulted in the chemical and pharmacological basis on the efficacy of some traditional medicines and medicinal plants having sedation.