DEVELOPMENTAL RESEARCH TO UTILIZE MICROORGANISM PRODUCTS HAVING POTENCY OF BIOFUNCTIONAL CONTROL FOR DRUG MATERIALS

Yamazaki从多型胶孢霉（Gelasinospora MULTIFORIS）、拟网状胶孢霉（Gelasinospora PSEUDORETICULATA）衍生的不育菌（Mycelia STERILIA）等子囊菌中分离出13种免疫抑制成分，其中12种为新成分，3种为单胺氧化酶抑制成分，3种为神经营养成分，Ohta从亚黑乳杆菌（Russula SUBNIGRICANS）、Iwasaki对几种具有抑制微管组装活性的天然产物的构效关系和作用机制进行了综述，这些天然产物包括：来自稻曲病菌（Ustilaginoidea VIRENS）的USTILOXIN A、来自海绵Dysidea ARENARIA的ARENASTATIN A、Tanaka等分离到4种新的GP 120-CD 4结合抑制剂，包括来自多色青霉的等色亲和素I和II，Nakagawa分离到的来自芽孢杆菌的褐藻酸酶和来自丝状真菌的青霉酸作为褐藻酸产生的抑制剂，IIDA阐明了Ca^++进入细胞的途径是由Trichosporins形成的离子通道，多孢不全孢霉的肽醇诱导儿茶酚胺的释放。Nagao用一种新改进的合成方法完成了从子囊菌Isaria SINCLAIRII中合成一种有效的免疫抑制成分的不对称全合成。Nakata成功地全合成了从云母海绵中合成的抗肿瘤成分Micalamide A和赤潮微生物Gymnodium BREVE的毒性成分Hemibrevetoxin B。

YAMAZAKI ISOLATED 13 IMMUNOSUPPRESSIVE COMPONENTS INCLUDING 12 NEW ONES,3 MONOAMINE OXIDASE INHIBITORY COMPONENTS,AND 3 NEUROTROPIC COMPONENTS FROM SOME ASCOMYCETES INCLUDING GELASINOSPORA MULTIFORIS,MYCELIA STERILIA DERIVED FROM GELASINOSPORA PSEUDORETICULATA,AND SO ON.OHTA ISOLATED SOME ANTITUMOR AND cAMP PHOSPHODIESTERASE-INHIBITORY COMPONENTS FROM SOME BASIDIOMYCETES INCLUDING RUSSULA SUBNIGRICANS,AND SO ON.IWASAKI INVESTIGATED STRUCTURE-ACTIVITY RELATIONSHIP AND FUNCTIONAL MECHANISM OF SOME NATURAL PRODUCTS HAVING POTENCY TO INHIBIT MICROTUBULE ASSEMBLY,USTILOXIN A FROM A FUNGUS USTILAGINOIDEA VIRENS,ARENASTATIN A FROM A SPONGE DYSIDEA ARENARIA,AND SO ON.TANAKA ISOLATED 4 NOVEL INHIBITORS AGAINST GP120-CD4 BINDING INCLUDING ISOCHROMOPHILONES I AND II FROM PENICILLIUM MULTICOLOR.NAKAGAWA ISOLATED ALGINATELYASE FROM BACILLUS SP.AND PENICILLIC ACID FROM A FILAMENTOUS FUNGUS AS AN INHIBITING PRINCIPLE AGAINST ALGINATE PRODUCTION.IIDA ELUCIDATED THAT THE INFLUX OF Ca^<++> INTO CELLS THROUGH ION CHANNELS FORMED FROM STIMULATION OF TRICHOSPORINS,PEPTAIBOLS FROM A FUNGI IMPERFECTI TRICHODERMA POLYSPORUM,INDUCED CATECHOLAMINE RELEASE.NAGAO ACCOMPLISHED ASYMMETRIC TOTAL SYNTHESIS OF A POTENT IMMUNOSUPPRESSIVE PRINCIPLE FROM AN ASCOMYCETE,ISARIA SINCLAIRII BY MEANS OF A NEWLY DEVELOPED SYNTHETIC METHOD.NAKATA WAS SUCCESSFUL IN TOTAL SYNTHESIS OF MICALAMIDE A,AN ANTITUMOR COMPONENT FROM A MICALE SPONGE,AND HEMIBREVETOXIN B,A TOXIC PRINCIPLE OF A RED TIDE MICROORGANISM,GYMNODIUM BREVE.