Extracellular rather than intracellular pathway plays an important role in attenuating thirst and drinking desirability during head-out immersion in hypohydrated men.

细胞外途径而不是细胞内途径在减少缺水男性的口渴和饮酒欲望方面发挥着重要作用。

• 批准号: 03454138
• 负责人: SHIRAKI Keizo
• 金额: $ 3.84万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454138/
• 关键词: Thirst; Plasma volume; Plasma osmolality; Plasma arginine vasopressin; Cardiopulmonary baroreceptors; Atrial natriuretic peptides; 尿量; 心房性ナトリウム利尿ペプチド; 頸下浸水; 脱水状態; AVP; 循環血液量; 細胞外液; 心房性ナトリウム利尿ペプタイド; ナトリウム利尿; 心拍出量; 脱水; バゾプレッシン(AVP); 心房性ナトリ

The purpose of this study was to investigate the mechanisms underlying a reduction of thirst sensation during head-out water immersion (HOI) in hypohydrated subjects. Eight males (19-25 yr) were subjected to thermoneutral HOI (water temperature ; 34.5ﾟC) and thermoneutral air (room temperature ; 28ﾟC) under two different conditions, euhydrated (Eu-H_2O and Eu-air) and hypohydrated (Hypo-H_2O, 3.8% weight loss after exercise in heat, Posm = +10 mosmol/kg and Hypo-air). Subjects were not allowed to drink throughout experimental periods. Thirst sensation on a visual analog scale with Hypo-H_2O was decreased (P<0.05) in 10 min of HOI.A significant attenuation of diuresis and a sustained increase in plasma volume occurred throughout HOI with Hypo-H_2O.In Eu-H_2O, however, a transient plasma expansion was observed early during HOI, while a remarkable diuresis was observed throughout HOI.There was a prompt and sustained increase (P<0.05) in the plasma level of atrial natriuretic peptides and a sustained decrease (P<0.05) in the plasma renin activity during HOI in both Eu-H_2O and Hypo-H_2O.Plasma arginine vasopressin decreased (P<0.05) during HOI in Hypo-H_2O but not in Eu-H_2O.The increment of stroke volume was greater (P<0.05) with Hypo-H_2O during HOI.Therefore, a greater increase (P<0.05) in stroke volume during HOI may suggest the greater stimulation of the mechanoreceptors with Hypo-H_2O.Plasma osmolality remained elevated in the presence of an attenuated thirst during HOI.Thus, the present results may support the hypothesis that the extracellular pathways may play an important role in reducing thirst sensation during HOI in hypohydrated subjects.

这项研究的目的是研究低水分受试者在头部浸水(HOI)过程中减少口渴感觉的机制。8名19~25岁男性受试者在两种不同的条件下，分别接受恒温HOI(水温：34.5ﾟC)和恒温空气(常温：28ﾟC)，正常水化(Eu-H2O和Eu-AIR)和低水化(Hypo-H2O，高温运动后体重下降3.8%，POSm=+10ﾟ/kg和低空气)。受试者在整个实验期间都不允许饮酒。在Hypo-H_2O的整个HOI过程中，利尿的显著减弱和血浆容量的持续增加。然而，Eu-H_2O在HOI的早期观察到一过性的血浆扩张，而在整个HOI中观察到显著的利尿。Eu-H_2O组和Hypo-H_2O组HOI时血浆肾素活性降低(P&lt；0.05)，而Eu-H_2O组血浆精氨酸加压素降低(P&lt；0.05)。HOI期间每搏输出量的增加可能表明低水H_2O对机械感受器的刺激作用更大。因此，本研究结果可能支持细胞外通路在HOI期间减轻口渴中起重要作用的假说。

项目成果

J.E.Greenleaf: "Effect of water temperature on cardiovascular responses to head-out immersion(HOl)." FASEBJ.6. A1838 (1992)

J.E.Greenleaf：“水温对头朝下浸泡 (HOl) 心血管反应的影响。”

S.Sagawa.: "Effect of dehydration on thirst and drinking during immersion in men." J.Appl. Physiol. 71(2). 128-134. (1992)

S.Sakawa.：“男性浸泡期间脱水对口渴和饮水的影响。”

Sueko Sagawa: "Effect of dehydration on thirst and drinking during immersion in men." J.Appl.Physiol.71. 128-134 (1992)

佐川末子：“脱水对男性浸泡期间口渴和饮酒的影响。”

K.SHIRAKI: "Effect of wafer temperature on cardiovascular responses to head-out immersion (HOI)." J.Appl.physiol.(1992)

K.SHIRAKI：“晶圆温度对头部浸入 (HOI) 心血管反应的影响。”

F.Wada: "Mechanisms of hypodipsia during head-out immersion." J.Appl.Physiol.(submitted). (1994)

F.Wada：“头朝外沉浸期间口渴的机制。”