Effect of thermoregulatory function on relationship between cardiopulmonary baroreceptors and body fluid hemeostasis

体温调节功能对心肺压力感受器与体液止血关系的影响

• 批准号: 07457018
• 负责人: SHIRAKI Keizo
• 金额: $ 4.93万
• 依托单位: University of Occupational and Environmental Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457018/
• 关键词: Continuous measurement; Plasma volume; Plasma osmolality; Plasma arginine vasopressin; Cardiopulmonary baroreceptors; Plasma electrolyte; 血管壁を介する水分移動; 二相性の変化; 体液組成分布; 血漿電解質; 血漿量; 密度連続測定装置; 体液ホメオスターシス; 血漿密度; 連続測定

The primary purpose of this study was to establish a system for measuring continuos blood volume and plasma electrolytes. In the next step, we designed to study the mechanisms responsible for the change in blood volume and electrolytes during an abrupt perturbation plasma volume in the following conditions in humans.1. An establishment of the measuring systems in combination of teh mechanical osicillator technique and ion-electrode method enabled us to measure a precise and continuous measurement of blood volume and plasma electrolytes during a course of hemodynamic perturbation in humans.2. Effect of vasomotor activity on plasma volume change during immersion was studied in 3 different water temperatures ; 32ﾟC at maximum vasoconstriction, 34.5ﾟC,thermoneutral, and 36ﾟC at minimmum vasoconstriction. A rapid reduction of blood and plasma densities in the first 20-25 min of imersion followed by a gradual reduction during the rest period of immersion. These changes were independent of th … More e water temperatures, sugesting that the volume of the transcapillary fluid shift is not modified by the vasomotor activity.3. A consistent hemoconcentration has been observed shortly after water drinking followed by a hemodilution (a biphasic change in blood volume). The mechanisms for this phenomenon was attributed to the outward shift of the fluid across the capillary walls because of the initial rise of blood presure and a later inward shift due to the postabsorptive mechanisms.4. A transient lowering of blood density immediately after lower body negative pressure (LBNP,-15 and -30 mmHg, for 10min) followed by a steep increase without reduction in plasma volume, indicating a redistribution of blood flow. The transcapillary fluid shift occurred -8 min after LBNP and returned to the original space in 20 during recovery.In conslusion, the present study proves that the on-line system of the present study is a useful tool for elucidate the mechanisms underlyting the transient and rapid fluid movement across the capilary walls in humans. Less

本研究的主要目的是建立一个连续测量血容量和血浆电解质的系统。下一步，我们设计研究在人类以下条件下血浆容量突然扰动期间血容量和电解质变化的机制。1。建立了机械振荡器技术与离子电极法相结合的测量系统，使我们能够在人体血流动力学扰动过程中精确、连续地测量血容量和血浆电解质。 2．研究了3种不同水温下浸泡过程中血管舒缩活性对血浆体积变化的影响；最大血管收缩时为 32°C，中性时为 34.5°C，最小血管收缩时为 36°C。在浸泡的前 20-25 分钟内，血液和血浆密度迅速降低，随后在浸泡的其余时间内逐渐降低。这些变化与水温无关，表明血管舒缩活动不会改变跨毛细血管液体转移的体积。3。在饮水后不久观察到血液浓度一致，然后进行血液稀释（血容量的双相变化）。这种现象的机制归因于最初血压升高导致液体穿过毛细血管壁向外移动，随后由于吸收后机制导致液体向内移动。4．降低身体负压（LBNP，-15 和 -30 mmHg，持续 10 分钟）后，血液密度立即短暂降低，随后血浆容量急剧增加，但血浆容量没有减少，表明血流重新分布。 LBNP后-8分钟发生跨毛细血管液体转移，并在恢复过程中20分钟返回原始空间。 总之，本研究证明本研究的在线系统是阐明人体毛细血管壁瞬时和快速液体运动的有用工具。较少的

项目成果

Wada Futoshi: "Mechanism of hyposipsia during head-out water immersion in men" Am. J.Physiol. (Regulatory Integrative Comp. Physiol.). 268. R583-R589 (1995)

和田富特志：“男性头部浸水时出现吸水功能减退的机制”Am。

Wada Futoshi: "Mechanism of hypodipsia during head-out water immersion in men." Am. J. Physiol.(Regulatory Integrative Comp.Physiol.). 268. R583-R589 (1995)

和田富特志（Wada Futoshi）：“男性头朝外浸水时出现口渴的机制。”

Shiraki Keizo: "Physiological Basis of Occupational Health:Stressful Environments" SPB Academic Publishing bv, 278 (1996)

白木庆三：“职业健康的生理学基础：压力环境” SPB 学术出版社 bv，278 (1996)

Torii Riko: "Mechanism for changes in vasopressin during acute exposure at 3 atm abs air" Am. J.Physiol. (Regulatory Integrative Comp. Physiol.). 273. R259-R264 (1997)

Torii Riko：“急性暴露于 3 atm 绝对空气时加压素变化的机制”Am。

Grernleaf John: "Is the Gauer-Henry reflex important for immersion diuresis in men?" J.Gravit. Physiol.(in press). (1998)

Grernleaf John：“高尔-亨利反射对于男性浸入式利尿很重要吗？”