Experimental radiological study for prevention and control of metastasis

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The specific goal of the present study was to establish lymphnode metastasis system(s) using C3H/HeJ mouse tumors and to investigate irradiation effect on metastatic development to lymphnodes. Mouse tumor systems of spontaneous origin named NFSA2ALM1 fibrosarcoma and NR-S1 squamous cell carcinoma were inoculated in the footpad of a hind leg. Metastatic lymphnode enlargement (confirmed by histology) was detected by about 2 weeks after the tumor cell inoculation, while clonogenic tumor cell release into the blood circulation started around 10 days and macroscopic lung nodules developed after 3-4 weeks of the tumor cell inoculation.Local tumor irradiatioon was found to suppress lymphnode metastatic development dose-dependently between 10 and 40 Gy.These results support and extend the conclusion of the previous study regarding 1) suppressive effect of local tumor irradiaiton on the clonogenic tumor cell release (CTCR) into the blood circulation and on the metastatic development to the lung, and 2) CTCR effeciency may predict the metastatic efficiency, i.e. high CTCR correlates to high spontaneous metastasis efficiency to the lung or lymphnodes.