Intravenous anesthetics and epinephrine-induced arrhythmias.

1.氟烷等烃类麻醉药可增强肾上腺素诱发的心律失常。关于静脉麻醉药，已报道硫喷妥钠比氟烷更能增强肾上腺素诱发的心律失常。然而，其他静脉麻醉药对肾上腺素诱导的心律失常的影响尚未得到很好的讨论。本研究旨在探讨异丙酚和依托咪酯对肾上腺素诱发犬心律失常的影响。结果表明，异丙酚可增强肾上腺素诱发的心律失常，而依托咪酯对肾上腺素诱发的心律失常无明显影响。此外，我们还发现在依托咪酯存在的情况下，丙泊酚的作用是剂量依赖性的。（麻醉学，1991）2。据报道，硫喷妥钠可使心脏对肾上腺素的促肾上腺素作用敏感，但与硫喷妥钠促肾上腺素作用有关的肾上腺素受体机制尚不清楚。我们研究了β-肾上腺素能受体和β-肾上腺素能受体在硫喷妥钠致敏犬心肌中的比较作用，证明β-肾上腺素能受体和β-肾上腺素能受体的活性在硫喷妥钠致敏犬心肌中对肾上腺素的促肾上腺素生成作用都是重要的.为了进一步研究肾上腺素诱发心律失常的肾上腺素受体机制，我们设计了一个实验模型，以阐明β 1和β 2肾上腺素受体在氟烷麻醉犬中的作用。(Can J Anaesth，1992）在我们的下一步工作中，我们打算阐明β肾上腺素受体亚型在硫喷妥钠麻醉期间心律失常发生中的作用。

1. It is well known that halothane and other hydrocarbon anesthetics enhance the epinephrine-induced arrhythmias. Regarding to intravenous anesthetics, thiopental has been reported to enhance the epinephrine-induced arrhythmias to a greater extent than did halothane. However, the effect of other intravenous anesthetics on epinephrine-induced arrhythmias has not been well discussed. Our study was designed to clarify the effect of propofol and etomidate on epinephrine-induced arrhythmias in dogs. The result is that, we clarified that propofol enhanced epinephrine-induced arrhythmias whereas etomidate did not have significant effect on epinephrine-induced arrhythmias. In addition, we determined that the action of propofol was dose-dependent in the presence of a background of etomidate. (Anesthesiology, 1991)2. Thiopental has been reported to sensitize the heart to the arrhythmogenic action of epinephrine, but the adrenoceptor mechanism involved in the arrhythmogenicity of thiopental remains unknown. We investigated comparative roles of alphal and beta adrenoceptors in myocardial sensitization by thiopental in dogs, and demonstrated that both alphal and beta adrenoceptor activities are important for myocardial sensitization by thiopental to the arrhythmogenic action of epinephrine.3. In order to extent our previous work on adrenoceptor mechanism of epinephrine-induced arrhythmias, we designed an experimental model to clarify the role of betal and beta2 adrenoceptor using halothane-anesthetized dogs. (Can J Anaesth, 1992) In our next work, we intend to elucidate the role of subtypes of beta adrenoceptor in the genesis of arrhythmias during thiopental anesthesia using this experimental model.