Studies on taste cognition processing by means of the gustatory evoked potential

利用味觉诱发电位研究味觉认知加工

• 批准号: 03454472
• 负责人: NARITA Yoshihiro
• 金额: $ 4.16万
• 依托单位: Tokyo Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454472/
• 关键词: Imipramine; Carbamazepine; Somatosensory evoked potential; Event related potential; Pain-related late positive component; Gustatory evoked potential; N100; Process of selecting the taste quality; P300

We analyzed analgesic effects of psychotropic drugs, imipramine and carbamazepin, quantitatively and objectively using somatosensory evoked potential (SEP) elicited by electric dental stimulation and event related potential (ERP) assessed by the right-left discriminatory response task by means of auditory stimulation. In SEP, N_2-P_2 amplitude (pain related late positive component) decreased significantly and N_2-peak latency was prolonged. In ERP, a significant decrease in amplitude of P_3 component (P 300) and prolongation of latency were observed. These suggested that psychotropic drugs would inhibit high CNS exhibiting analgesic effect secondarily.Next, we recorded gustatory evoked potential (GEP) elicited by electric stimulation of the tongue to assess gustation objectively and quantitatively by comparing subjective sensation with GEP and SEP wave shapes. An increase in electric intensity resulted in a significant increase in N_2-P_2 amplitude of SEP. Furthermore, in GEP when gustation was induced, N 100 which is a characteristic negative component appeared between N_1 and P_1 of SEP. N100 reflected the acceptance and transmission processes for information on taste and was suggested as a component related to the process of selecting taste quality.

采用电牙刺激诱发的体感诱发电位（SEP）和听觉刺激左右辨别反应任务评定的事件相关电位（ERP），定量客观地分析了精神药物丙咪嗪和卡马西平的镇痛作用。SEP中N_2-P_2波幅（痛相关迟发性正波）明显降低，N_2峰潜伏期延长。ERP中P3波（P300）波幅降低，潜伏期延长.其次，我们记录了电刺激舌诱发的味觉诱发电位（gustatory evoked potential，GEP），通过比较主观感觉与GEP和SEP波形，客观定量地评价味觉。在GEP中，诱发味觉时，在SEP的N_1和P_1之间出现了特征性的负成分N100，它反映了味觉信息的接受和传递过程，是与味觉品质选择过程有关的成分。

项目成果

松崎 俊哉: "口腔領域における向精神薬の鎮痛効果に関する研究ー大脳誘発電位を指標としてー" 日本口腔外科学会雑誌. 38. 1791-1808 (1992)

松崎敏也：“精神药物在口腔中的镇痛作用的研究-以脑诱发电位为指标”日本口腔颌面外科学会杂志38。1791-1808（1992）。

脇 要: "舌電気刺激による誘発電位に関する研究"

Kaname Waki：“舌电刺激诱发电位的研究”

Toshiya Matsuzaki: "The effect of analgesia by psychotropic drugs in the oral and maxillofacial region -Using the cerebral evoked potential as an indicator-" Japanese Journal of Oral and Maxillofacial Surgery. Vol.38. 1791-1808 (1992)

松崎敏也：“口腔颌面部精神药物的镇痛效果-以脑诱发电位为指标-”日本口腔颌面外科杂志。

Kaname Waki: "Studies on evoked potential elicited by electric stimulation of the tongue"

Kaname Waki：“对舌头电刺激引起的诱发电位的研究”

松崎 俊哉: "口腔領域における向精神薬の鎮痛効果に関する研究-大脳誘発電位を指標として-" 日本口腔外科学会雑誌. 38. 1791-1808 (1992)

松崎敏也：“精神药物在口腔区域的镇痛作用的研究——以脑诱发电位为指标”日本口腔颌面外科学会杂志38。1791-1808（1992）。