Investigating the mechanisms of flavonoid actions on glycine receptors

研究类黄酮对甘氨酸受体的作用机制

• 批准号: DP0557657
• 负责人: A/Prof Andrew Moorhouse
• 金额: $ 20.8万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557657
• 关键词: Investigating; mechanisms; flavonoid; actions; glycine

The research to be conducted in this project will use state-of-the-art electrophysiological and molecular biological approaches to carefully characterise the actions of certain flavonoid compounds on the glycine-receptor channel. These compounds have recently been reported to act as modulators of ligand-gated ion channels, proteins integral to brain function and disease. However, no-one has studied in any detail the mechanisms by which these compounds act. By discovering their site and mechanisms of action we will further our understanding of these important proteins and their modulation, maintain Australia's significant expertise in this field and provide leads for future development of drugs with potential therapeutic value.

本项目的研究将使用最先进的电生理学和分子生物学方法，仔细研究某些类黄酮化合物对甘氨酸受体通道的作用。 这些化合物最近被报道作为配体门控离子通道的调节剂，蛋白质是脑功能和疾病的组成部分。 然而，没有人详细研究过这些化合物的作用机制。 通过发现它们的作用位点和机制，我们将进一步了解这些重要的蛋白质及其调节，保持澳大利亚在这一领域的重要专业知识，并为未来开发具有潜在治疗价值的药物提供线索。