Divarsity of Perfluorochemicals in nature

全氟化学品（FDA）具有两种优异的性能，一是作为良好的氧载体，二是作为肿瘤和肝脏显像剂。去年，我们使用^<31 b> p -磁共振波谱（MRS）从移植的SCCVII肿瘤中磷酸盐能量代谢的变化来检测FDA的放射增敏作用（作为氧载体）。PCr/Pi在SCC VII肿瘤获得的^<31>P-MR光谱的所有参数中变化最为显著，与肿瘤生长高度相关。从实验组（对照组、放疗组、氧组、FDA组）肿瘤生长延迟和^<31>P-MRS （PCr/Pi）的结果来看，FDA具有放射增敏作用，^<31>P-MRS （PCr/Pi）可用于监测放射增敏剂、放射治疗、化疗和治疗后再生的效果。今年，FDA的F-MRS （9.4T, GSX400: JEOL）和F-MRI （4.7T, CSI Omega2: Bruker）分别测量了^<19>和^<19>。FDA ^<19>F-MR光谱中的f峰面积检测到0.02%FDA。从荷瘤小鼠肝脏获得的^<19>F-MR光谱中，在注射FDA后的第1天至第20天，f峰面积增加，然后下降。小鼠肿瘤的F-MR光谱中^<19>的f峰面积在注射FDA后第1天增加，并随着肿瘤的生长而减小。^<19>的F-MRI成像检测到FDA的0.67%。注射FDA (40ml/kg) 2天后，肝脏和小鼠均能以^< 19b>的F-MRIFDA显像，可作为放射增敏剂用于放疗，也可作为肿瘤显像剂用于诊断。

Perfuluorochemicals (FDA) have two excellent properies, as a good carrier of oxygen and as a imaging agent for tumor and liver. Last year, we examined the radiosensitizing effect (as a oxxgen carrier) of FDA from the changes of phosphate enegy metabolism in transplanted SCCVII tumor using ^<31>P-Magnetic Resonance Spectroscopy (MRS). PCr/Pi showed the most remarkable change among all parameters of ^<31>P-MR spectra obutained from SCC VII tumor and high correlation with tumor growth. From the results of tumor growth delay and ^<31>P-MRS (PCr/Pi) in experimental groups (control, irradiation, oxygen, FDA group), it was concluded that FDA had the radiosen-sitizing effect, and ^<31>P-MRS (PCr/Pi) was useful for monitoring the effects of radiosensitizer, radiation therapy, chemothermia and regrowth after these therapy.In this year, ^<19>F-MRS (9.4T, GSX400 : JEOL) and ^<19>F-MRI (4.7T, CSI Omega2 : Bruker) of FDA were measured. ^<19>F-peak area in ^<19>F-MR spectra of FDA was detected to 0.02%FDA.^<19>F-peak area in ^<19>F-MR spectra obtained from liver in tumor bearing mouse increased from 1day to 20days after injection of FDA and then decreased. ^<19>F-peak area in ^<19>F-MR spectra obtained from tumor in mouse increased 1day after injection of FDA and decreased according to the growth of tumor. Imaging of FDA was detected to 0.67% of FDA by ^<19>F-MRI.Two days after injection of FDA (40ml/kg), liver and mouse were able to image by ^<19>F-MRIFDA might be useful both in radiotherapy as a radiosensitizer and in diagnosis as a tumor imaging agents.