New assessment of anti-tumor drug, 5-FU by using 19F-MRI and 19-MRS

19F很有希望成为下一代核磁共振的核心。因为，19F的参考频率接近质子，灵敏度很高。19F是细胞核不在体内。19F的成像和光谱显示了体内注射药物的特性。首先，用newl9F-pH探针的19F-MRS测量细胞外pH值，用31P-MRS测量细胞内pH值，结果表明，随着肿瘤的生长，两种pH值同时下降，细胞外pH值低于细胞内pH值，且比细胞内pH值有所延迟。新coli-2的敏感性最高，适于动物实验。因此，用新线圈2进行了以下实验。5-FU在肝脏中的降解过程变得清晰。5-FU在肿瘤中的降解速度比肝脏慢，且持续时间长。同时，我们检查了5-FU的前体，tegful被检查了，因为准备新的线圈进行19F-MRI是困难的，很失望的是，19F-MR不能对这些进行成像。

19F is promising as a nucleus of MR of the next generation. Because, reference frequency of 19F is close to the proton and its sensitivity is very high. 19F is the nucleus is not here in vivo. Imaging and spectra of 19F show the character of the drug which is injected in vivo.At first, at the same time, extracellular pH was measures by using 19F-MRS of newl9F-pH probe, we measured intracellular pH from the chemical shift of Pi in 31P-MRS, These results showed that both pHs declined together according to the growth of the tumor and extracellular pH is lower than the intracellular pH and it was delayed compared to intracellular pH.New 4 coils were examine by using surface coil in this research funs. The sensitivity of new coli-2 was the highest and coil-2 was suitable for the animal experiment. So, the following experiments were done by the new coil-2.The degradation process of 5-FU in liver became clear. The degradation of 5-FU in tumor was slower than the liver, and remained long. And also, we examined about the precursor of 5-FU, Tegaful was examinedBecause the preparation of new coil for 19F-MRI was difficult, it was disappointed that 19F-MR imaging for these couldn't be taken.