BIOLOGICAL EVALUATION OF HYDROXYAPATITE BY HIGH-VELOCITY FLAME SPRAYING TECHNIQUE

高速火焰喷涂技术对羟基磷灰石的生物学评价

• 批准号: 04454515
• 负责人: OGUCHI Hitoshi
• 金额: $ 4.1万
• 依托单位: TSURUMI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454515/
• 关键词: High-Velocity Flame-Spraying technique; Hydroxyapatite; Biological Evaluation; S.E.M.; 骨膜; 表面性状; 初期反応; ハイドロキシアパタイト; プラズマ溶射法

In 1988, we have developed a high-velocity flame-spraying technique for applying HA onto titanium alloys. From our results (comparative study ; HVFS-HA and Plasma-HA), we have understood as follows ;(1). From X-ray diffraction pattern analysis, the HA layr of both Plasma-HA and HVFS-HA showed a well maintained structual pattern characteristic of HA.However, the Plasma-HA on the plate was oriented to the C axis of HA.(2). In regard to surface microstructure, HVFS-HA was much more porous than plasma-HA and plasma-HA showed microbreakage due to the rapid reduction in temperature.(3). Solubility tests indicated the pH values of Plasma-HA and HVFS-HA to be comparable. The solubility of Ca was higher for Plasma-HA than HVFS-HA.(4). In vivo, the thickness of coated HA layr tended to decreased at 1 month, 3 months, 6 months and 1 year for both Plasma-HA and HVFS-HA.However, Plasma-HA showed a greater decrease in thickness than did HVFS-HA,although the difference was not significant.(5). From biological findings, in the first month, Plasma-HA was superior to HVFS-HA and prominent bone was noted on the surface of Plasma-HA and 3 months, 6 months and 1 year, there were no differences biologically.

1988年，我们开发了一种高速火焰喷涂技术，用于在钛合金上喷涂HA。从我们的结果（比较研究; HVFS-HA和Plasma-HA），我们理解如下：（1）. X射线衍射分析表明，Plasma-HA和HVFS-HA的HA层均保持了HA的结构特征，但Plasma-HA在板上的取向与HA的C轴方向一致。（二）、在表面微观结构方面，HVFS-HA比等离子体-HA多孔得多，并且等离子体-HA由于温度的快速降低而显示出微断裂。（三）、溶解度测试表明Plasma-HA和HVFS-HA的pH值相当。Plasma-HA的Ca溶解度高于HVFS-HA。（四）、在体内，Plasma-HA和HVFS-HA的HA涂层厚度在1个月、3个月、6个月和1年时均呈下降趋势，但Plasma-HA涂层厚度的下降幅度大于HVFS-HA，但差异不显著。（五）、从生物学结果来看，在第一个月，Plasma-HA上级HVFS-HA，在Plasma-HA表面上观察到突出的骨，并且在3个月、6个月和1年时，生物学上没有差异。

项目成果

尾口仁志: "HAコーティングの現在と課題" Quintessence Dental Implantology. 1. 40-47 (1994)

Hitoshi Oguchi：“HA 涂层的现状和问题”Quintessence Dental Implantology 1. 40-47 (1994)。

Hitoshi OGUCHI: "In Vivo Evaluation of Hydroxyapatite Sprayd by Different Coating Methods" Bioceramics Volume. 7. 215-221 (1994)

Hitoshi OGUCHI：“不同涂层方法喷涂羟基磷灰石的体内评价”生物陶瓷卷。

H.OGUCHI: "In Vivo Evahration of Hgdroxyapatite Sprayed by Different Coating Methods" Bioceramics. 7. 215-221 (1994)

H.OGUCHI：“通过不同涂层方法喷涂羟基磷灰石的体内蒸发”生物陶瓷。

尾口仁志: "HAコーティングの現在と課題" Quintessence Dental Implantology(クインテックス・デジタル・インプラントロジー). 1. 40-47 (1994)

Hitoshi Oguchi：“HA 涂层的现状和问题”Quintessence Dental Implantology 1. 40-47 (1994)。

H.OGUCHI: "In Vivo Evaluation of Hydroxyapatite Sprayed by Different Coating Methods21GC01:Bioceramics" 7. 215-221 (1994)

H.OGUCHI：“不同涂层方法喷涂羟基磷灰石的体内评价21GC01：生物陶瓷”7. 215-221 (1994)