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Study on interspecies-difference in tissue distribution of weakly basic drugs and prediction of the distribution in human

Study on interspecies-difference in tissue distribution of weakly basic drugs and prediction of the distribution in human
弱碱性药物组织分布种间差异研究及人体分布预测
批准号：
04454533
负责人：
YATA Noboru
金额：
$2.18万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1992
资助国家：
日本
项目状态：
已结题
起止时间：
1992 至 1994
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454533/
关键词：
Tissue distributionQuinidineWeakly basic drugsPhosphatidylserineRatsMiceRabbitsGuinea-pigsフォスファチジルセリン塩基性薬物ホスファチジルセリン含量種差相互作用アニマルスケールアップヒトでの分布予測

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中文摘要
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英文摘要
The role of phosphatidylserine (PhS) in the tissue distribution of quinidine (Kp value) was investigated in CCI_4-intoxicated rats, turpentine-treated rats, normal rabbits, normal mice and normal guinea-pigs.In all animal models, a linear relationship between the Kp value of unbound quinidine in plasma and tissue PhS concentration in various tissues was observed.Also, the obtained Kp values were almost comparable among different animals examined.These results indicate that PhS is a determinant in tissue distribution of quinidine in experimental animals, and no interspecies-difference was observed.Above finding may indicate that the Kp value of weakly basic drugs in human is also predictable from the relationship between the Kp value of unbound drug concentration in plasma and tissue PhS concentration in experimental animals.
期刊论文(12)
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会议论文
N.Sugihara,: "The influence of increased plasma protein binding on the disposition of quinidine in turpentine-treated rats" Biological & Pharmaceutical Bulletin. 16. 63-67 (1993)
N.Sugihara，：“血浆蛋白结合增加对松节油处理大鼠奎尼丁处置的影响”生物
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通讯作者：
Noboru Yata: "Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats" Pharmaceutical Research. 7. 1019-1025 (1990)
Noboru Yata：“磷脂酰丝氨酸作为大鼠弱碱性药物组织分布的决定因素”药物研究。
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通讯作者：
N.Sugihara, K.Furuno, N.Kita, T.Murakami, N.Yata: "The influence of increased plasma protein binding on the disposition of quinidine in turpentine-treated rats" Biol. Pharm. Bull.16、. 63-67 (1993)
N.Sugihara、K.Furuno、N.Kita、T.Murakami、N.Yata：“血浆蛋白结合增加对松节油处理大鼠奎尼丁处置的影响”Biol Bull.16，。 67（1993）
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通讯作者：
Akio Nishiura: "A possible contribution of Phospholipids in tissue distribution of quinidine in rats" Journal of Pharmacobio-Dynamics. 9. 819-828 (1986)
Akio Nishiura：“磷脂对大鼠奎尼丁组织分布的可能贡献”《药物生物动力学杂志》。
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共 6 条
    Evaluation of bases for topical preparations by microdialysis
    • 批准号：
      09672203
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.73万
    • 财政年份：
      1997
    • 负责人：
      YATA Noboru
    • 依托单位：
      Setsunan University
    海外基金