Thoracic sympathectomy for the treatment of ventricular tachyarrhymias

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It is known that congenital hypofunction of right-sided sympathetic activity is one of the main cause of Long QT Syndrome (LQTS). As the result of this malfunction, left-sided sympathetic activity through left stellate ganglion become relatively larger than normal condition. High frequency component of QRS complex is also affected by catecholamine. Especially, stimulation of beta-adrenergic receptor induces the decrement of high frequency component through the suppression of Na^+ fast channel depolarization and prolongs the QRS duration for that reason. In this study, prolonged QRS duration in high frequency bands was found in both stimulation of left stellate ganglion by electrical spike and injection of isoproterenol. From those results, detection of high frequency component of QRS complex may be useful method for both recognition of LQTS and effectiveness of treatment after surgical resection of left stellate ganglion in patients with LQTS.