Thoracic sympathectomy for the treatment of ventricular tachyarrhymias

胸交感神经切除术治疗室性心动过速

• 批准号: 04807097
• 负责人: MITSUI Toshio
• 金额: $ 1.28万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04807097/
• 关键词: Long QT syndrome; signal-averaged ECG; inhomogeneity of sympathetic nerve system; ventricular tachycardia; autonomic agent; RMST; QRSD; beta-adrenergic receptor; 自立神経薬; 星状神経節; 交感神経支配不均衡; 上室性頻拍; RMS_<40>; 星状神経節ブロック; 交感神経緊張不均衡; 難治性不整脈; 局所的興奮

It is known that congenital hypofunction of right-sided sympathetic activity is one of the main cause of Long QT Syndrome (LQTS). As the result of this malfunction, left-sided sympathetic activity through left stellate ganglion become relatively larger than normal condition. High frequency component of QRS complex is also affected by catecholamine. Especially, stimulation of beta-adrenergic receptor induces the decrement of high frequency component through the suppression of Na^+ fast channel depolarization and prolongs the QRS duration for that reason. In this study, prolonged QRS duration in high frequency bands was found in both stimulation of left stellate ganglion by electrical spike and injection of isoproterenol. From those results, detection of high frequency component of QRS complex may be useful method for both recognition of LQTS and effectiveness of treatment after surgical resection of left stellate ganglion in patients with LQTS.

众所周知，先天性右侧交感神经活动功能低下是长QT综合征的主要原因之一。由于这种功能障碍，通过左星状神经节的左侧交感神经活动相对大于正常情况。QRS复合体的高频成分也受儿茶酚胺的影响。特别是β -肾上腺素能受体的刺激通过抑制Na^+快速通道去极化导致高频成分的衰减，从而延长QRS持续时间。本研究发现，电脉冲刺激左星状神经节和注射异丙肾上腺素均能延长高频段QRS持续时间。从这些结果来看，检测QRS复合物的高频成分可能是识别LQTS和有效治疗LQTS患者手术切除左星状神经节的有效方法。

项目成果

三井 利夫: "心臓外科領域でのSignal-averagingの応用" Therapeutic Research. 13(8). 3409-3417 (1992)

Toshio Mitsui：“信号平均在心脏手术中的应用”治疗研究 13(8) (1992)。

松下 昌之助, 三井 利夫他: "開心術後重症心不全に対する補助循環の適応と離脱の指標としてのsignal-averaged ECG" 心臓. 24(Suppl4). 7-11 (1992)

Masanosuke Matsushita、Toshio Mitsui 等人：“信号平均心电图作为心脏直视手术后严重心力衰竭的适应和退出的指标”Cardiac 24（Suppl4）。