Basic study of heart rate variability using chick embryo

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To make clear the relation of fetal heart rate variability (FHRV) with the environmental conditions, simulation experiments using chick embryo were made in following subjects.1) picking up heart beat noninvasively from chick embryo2) producing the cardiotacogram of chick embryo3) control temperature and humidity in experimental box4) measurement of HRV of chick embryo while changing temperature5) dependency of O_2 and CO_2 on HRV of chick embryo6) dependency of embryo movement on HRV of chick embryo7)influence of other environmental factors (intensive magnetic field, electro-magnetic wave, ultrasonic wave) to HRV of chick embryoThe subjects of 1), 2) and 3) which is bearing basic instrumentation were realized. Heart beat was detected by the two methods of optical plethysmograph and phonocardiograph from 4 days after incubation, and the heart rate variability was obtained in relation to change of the environmental factors such as temperature, O_2 and CO_2 concentration and embryonic movement. The results of the simulation experiments by chick embryo showed the analogous phenomena to fetal heart rate variability (FHRV) of human being.