权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Responses in Extraocular Muscles from Magnetic Stimulation

磁刺激引起的眼外肌反应

基本信息

批准号：
05454480
负责人：
MIMURA Osamu
金额：
$ 2.43万
依托单位：
Hyogo College of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454480/
关键词：
Magnetic Stimulation Extraocular Muscle Electromyography

项目摘要

Purpose. This experiments were performed to investigate the origin of evoked action potentials of cat extraocular muscles by a pulsed magnetic stimulus through a circular coil or a pair of oppositely connected coils, which is placed on the scalp.Methods. Pulsed magnetic stimuli were applied to the scalp in twelve normal cats while recording electromyographical responses (EMGs) from the extraocular muscles (superior rectus, lateral rectus and inferior oblique muscles) with concentric needle electrodes. To investigate origin of magnetic evoked action potentials in extraocular muscles, alteration of EMG from lateral rectus muscle was compared before and after dissecting tectopontine pathway in five cats.Results. In all normal cats, action potentials of single neuro-muscular unit were easily recorded in all muscles examined with latency of 3.2-37.5ms (mean 15.6ms). These responses disappeared either after intravenous administration of pancuronium bromide, or by amputation of the peripheral corresponding nerve. By dissecting tecto-pontine pathway, magnetic evoked action potential with latency of approximately 15-25ms were disapeared.Conclusions. In ophthalmological field, there is no investigation of the magnetic evoked electromyography in extraocular muscles due to difficulties in both stimulation and recording. In this study magnetic evoked action potentials in extraocular muscles can be classified into two groups according to their latency, i.e.those with short latency (about 5ms), those with long latency (>15ms). Ablation experiment suggested that magnetic response with long latency was origineted in midbrain and/or cerebral cortex, and those with shory latency, therefore, in pons.

目的。本实验通过放置在头皮上的圆形线圈或一对相对连接的线圈，通过脉冲磁刺激，研究猫眼外肌诱发动作电位的来源。在12只正常猫的头皮上施加脉冲磁刺激，同时用同心针电极记录眼外肌(上直肌、外直肌和下斜肌)的肌电反应(EMG)。为了探讨眼外肌磁诱发动作电位的起源，比较了5只猫切断顶盖桥脑通路前后外直肌肌电的变化。正常猫的所有肌肉均可记录到单个神经肌肉单位的动作电位，潜伏期3.2~37.5ms，平均15.6ms。静脉注射潘库溴铵或切断相应的外周神经后，这些反应消失。通过对顶盖-桥脑通路的解剖，发现潜伏期约为15~25ms的磁诱发动作电位。在眼科领域，由于刺激和记录的困难，眼外肌的磁诱发肌电尚未见报道。本研究将眼外肌磁诱发动作电位按潜伏期分为短潜伏期(约5ms)和长潜伏期(15ms)两组。消融实验表明，长潜伏期的磁反应起源于中脑和/或大脑皮层，因此潜伏期较长的磁反应起源于脑桥。