The effect of cementum protein-impregnated HAP on the formation of new attachment

本研究旨在评价牙骨质成分诱导种植体周围牙周韧带样组织形成的可能性。将含有和不含有牛骨水泥颗粒的羟基磷灰石(HA)种植体分别植入实验制作的猴颌无牙牙列。3个月后处死动物，取出种植体，用切割-格网系统进行准备。未脱钙切片的组织学检查显示，羟基磷灰石种植体周围有与牙周膜一致的组织形成，而未包裹明胶的羟基磷灰石种植体未见牙周组织形成。结果表明，HA种植体周围的组织与真正的牙周膜一致，表面覆盖有牙骨质。这项技术可能会被证明是治疗上有用的，作为更自然和功能更好的人工牙替换的辅助手段。

This study was carried out to evaluate the potential of cemental components to induce formation of periodontal ligament-like tissue around dental implants. Hydroxyapatite (HA) implants compounded with and without bovine cemental particles were placed in experimentally created edentulous ridges of monkey jaws. After 3 months animals were sacrificed, and implants were retrieved and studied following preparation with the cutting-griding system. Histologic examination of undecalcified sections revealed that tissue consistent with periodontal ligament was formed surrounding hydroxyapatite implants when coated with gelatine-embedded cemental particles, whereas no such periodontal tissue was observed on the HA implants without cemental particles. Results demonstrate that tissue consistent with a true periodontal ligament from around HA implants coated with cementum. This technique may prove therapeutically useful as an adjunct to more natural and functional artificial tooth replacement.