2 Head centrifuge electrospinning device with integrated 3D printer

我们的研究重点是结构蛋白的分析和表征及其作为医疗器械创新高性能材料的应用。我们的研究中心是材料和方法的开发，为再生医学提供支架。蛋白质材料的加工技术包括生产纤维、非织造网、膜、泡沫、颗粒以及水凝胶的方法。纤维生产技术包括湿法、静电、仿生和微流体纺丝装置。对于药物载体系统、组织支架和生物制造等应用，生成2D和3D支架的需求很高。因此，有必要克服现有的问题，例如关于所需形态（例如高分辨率3D结构）的灵活性或传统电纺丝的处理速度。此外，有必要在一个装置内组合联合收割机各种技术，例如电子纺丝和3D打印。该解决方案是一种新型的离心静电纺丝装置，用于（生物）聚合物纺丝原液。新设备将2个纺丝头与3D打印机结合在一起，包括熔融电写入设备以及后处理室。在线流变仪、高速摄像机和数字过程控制软件等在线分析工具可实现最佳的参数控制。静电纺丝（CES）是一种将离心力、静电力和重力结合在一起的纤维加工技术，这些力都作用在纺丝喷嘴上。在这些力高于表面张力和粘性阻力的情况下，射流将被完全拉长并产生超薄纤维。因此，CES将两种技术的优点结合在一起。为了在分层结构的3D支架中实现新的功能性非织造材料，新型双头CES与集成的3D打印机结合了2个纺丝头，用于同时纺丝2个单独的纺丝原液，并允许连续生产以及相关参数的详细在线分析。无论是拜罗伊特大学还是我们的任何合作伙伴都没有这样的机器。

Our research focusses on analysis and characterization of structural proteins and their application as innovative high performance materials for medical devices. In the center of our research is the materials as well as methods development to provide scaffolds for regenerative medicine amongst others. Processing technologies for the protein materials encompass methods to produce fibers, nonwoven meshes, films, foams, particles as well as hydrogels. Amongst the fiber production techniques are wet, electro, biomimetic and microfluidic spinning setups. The need to generate 2D and 3D scaffolds for applications as drug carrier systems, tissue scaffolds and biofabrication is high. Therefore, it is necessary to overcome existing problems e.g. concerning the flexibility of the desired morphologies (such as high resolution 3D structures) or the processing speed of traditional electrospinning. Further, it is necessary to combine various techniques such as e-spinning and 3D printing within one device. The solution is a novel type of centrifuge electrospinning device to be used for (bio)polymeric spinning dopes. The new device combines 2 spinning heads with a 3D printer with an included melt electro writing device, as well as a post treatment chamber. Online analytics tools such an inline rheometry, high-speed cameras and a digital process control software allow for the best possible parameter control. Centrifuge electrospinning (CES) is a fiber processing technique combining centrifugal, electrostatical and gravimetric forces, which all operate on the spinning jet. In case these forces are higher than the surface tension and the viscosity resistance, the jet will be fully elongated and ultra-thin fibers are produced. CES therefore combines the advantages of two techniques in one. To enable new functional nonwoven materials within hierarchically structured 3D scaffolds, the novel 2 head CES with an integrated 3D printer combines 2 spinning heads for simultaneously spinning 2 individual spinning dopes and allows for the continuous production as well as a detailed online analysis of relevant parameters. Neither the University of Bayreuth nor any of our collaboration partners have such machine.