2 Head centrifuge electrospinning device with integrated 3D printer

我们的研究集中在结构蛋白的分析和表征及其作为创新的高性能医疗设备材料上的应用。我们研究的中心是为再生医学提供支架的材料和方法的开发等。蛋白质材料的加工技术包括生产纤维、非织造网状物、薄膜、泡沫、颗粒以及水凝胶的方法。纤维生产技术包括湿法、电纺丝、仿生纺丝和微流控纺丝。对于用于药物载体系统、组织支架和生物制造的2D和3D支架的需求是很高的。因此，有必要克服现有的问题，例如关于所需形貌的灵活性(如高分辨率3D结构)或传统电纺的处理速度。此外，有必要在一个设备中结合各种技术，如电子纺纱和3D打印。该溶液是一种用于(生物)聚合物纺丝的新型离心机静电纺丝装置。新设备将两个旋转头、3D打印机、包括熔化电写设备以及后处理室结合在一起。在线分析工具，如在线流变仪、高速摄像机和数字过程控制软件，可实现最佳的参数控制。离心机静电纺丝(CES)是一种结合离心力、静电力和重力的纤维加工技术，离心力、静电力和重力都在纺纱喷嘴上运行。如果这些力高于表面张力和粘度阻力，喷嘴将被完全拉长，并产生超细纤维。因此，CES将两种技术的优点结合在一起。为了在分层结构的3D支架中实现新的功能非织造材料，带有集成3D打印机的新型双头CES结合了两个纺纱头，可同时纺制两个单独的纺丝浆料，并允许连续生产以及相关参数的详细在线分析。拜罗伊特大学和我们的任何合作伙伴都没有这样的机器。

Our research focusses on analysis and characterization of structural proteins and their application as innovative high performance materials for medical devices. In the center of our research is the materials as well as methods development to provide scaffolds for regenerative medicine amongst others. Processing technologies for the protein materials encompass methods to produce fibers, nonwoven meshes, films, foams, particles as well as hydrogels. Amongst the fiber production techniques are wet, electro, biomimetic and microfluidic spinning setups. The need to generate 2D and 3D scaffolds for applications as drug carrier systems, tissue scaffolds and biofabrication is high. Therefore, it is necessary to overcome existing problems e.g. concerning the flexibility of the desired morphologies (such as high resolution 3D structures) or the processing speed of traditional electrospinning. Further, it is necessary to combine various techniques such as e-spinning and 3D printing within one device. The solution is a novel type of centrifuge electrospinning device to be used for (bio)polymeric spinning dopes. The new device combines 2 spinning heads with a 3D printer with an included melt electro writing device, as well as a post treatment chamber. Online analytics tools such an inline rheometry, high-speed cameras and a digital process control software allow for the best possible parameter control. Centrifuge electrospinning (CES) is a fiber processing technique combining centrifugal, electrostatical and gravimetric forces, which all operate on the spinning jet. In case these forces are higher than the surface tension and the viscosity resistance, the jet will be fully elongated and ultra-thin fibers are produced. CES therefore combines the advantages of two techniques in one. To enable new functional nonwoven materials within hierarchically structured 3D scaffolds, the novel 2 head CES with an integrated 3D printer combines 2 spinning heads for simultaneously spinning 2 individual spinning dopes and allows for the continuous production as well as a detailed online analysis of relevant parameters. Neither the University of Bayreuth nor any of our collaboration partners have such machine.