Molecular principles of ER-phagy pathways (D05*)

内质网(ER)被动态重塑以使其结构适应细胞的需要。这一过程是通过涉及网状受体FAM134B和RTN3的选择性自噬(ER-吞噬)来介导的。在这里，我们建议分析ER-吞噬受体FAM134B是如何调节的，以及如何驱动货物选择。特别是，我们将研究FAM134B的相互作用组，以确定潜在的ER吞噬调节因子。此外，我们的目标是进一步研究可能作为FAM134B辅助受体的ER伴侣Calnexin(CanX)和Sigma-R1在ER吞噬中的作用。综上所述，这项研究将有助于破译内质网吞噬在维持内质网规模、功能和营业额方面的作用。

The endoplasmic reticulum (ER) is dynamically remodeled to adapt its structure to cellular needs. This process is mediated via selective autophagy (ER-phagy) involving reticulon-type receptors, namely FAM134B and RTN3. Here, we propose to analyze how the ER-phagy receptor FAM134B is regulated and how cargo selection is driven. In particular, we will investigate the interactome of FAM134B to identify potential regulators of ER-phagy. In addition, we aim to further study the role of ER chaperones Calnexin (CANX) and SIGMA-R1 that may act as FAM134B co-receptors for ER-phagy. Taken together, this study will help deciphering the role of ER-phagy in maintaining ER size, functionality, and turnover.