Molecular principles of ER-phagy pathways (D05*)

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The endoplasmic reticulum (ER) is dynamically remodeled to adapt its structure to cellular needs. This process is mediated via selective autophagy (ER-phagy) involving reticulon-type receptors, namely FAM134B and RTN3. Here, we propose to analyze how the ER-phagy receptor FAM134B is regulated and how cargo selection is driven. In particular, we will investigate the interactome of FAM134B to identify potential regulators of ER-phagy. In addition, we aim to further study the role of ER chaperones Calnexin (CANX) and SIGMA-R1 that may act as FAM134B co-receptors for ER-phagy. Taken together, this study will help deciphering the role of ER-phagy in maintaining ER size, functionality, and turnover.