Development of Functional Ultrasonic Contrast Agent

功能性超声造影剂的研制

• 批准号: 05650055
• 负责人: MORIYA Tadashi
• 金额: $ 1.34万
• 依托单位: Tokyo Metropolitan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05650055/
• 关键词: ultrasoni contrast agent; blood flow; magnetic microspheres; motion fields; ultrasonic tracer; 造影剤; 磁性体; 中空微粒子; 共鳴

Main results obtained in this research are as follows ;1. An ultrasonic contrast agent which can be controlled by an external magnetic field, and whose specific gravity is adjustable to that of the ambient fluid is developed. The agent is made of hollow two-layred spheres.2. A resonant type ultrasonic tracer is developed and the relation between the resonance frequency and the diameter of hollow magnetic micro spheres is clarfied. Flow visualization of slow fluid flow was demonstrated using this tracers.3. A new approach for the detection and computation of two dimensional field using image sequence is presented. This computational model has a multi-channel motion detector. Experimental results shows that this model detects more reliable motion fields compared to one-channel model.3. The approach was applied for the detection of blood flow.

本研究取得的主要成果如下：1.研制了一种超声造影剂，它可以由外部磁场控制，并且其比重可以根据周围流体的比重进行调节。该药剂由中空的双层球体组成.研制了一种谐振式超声示踪剂，阐明了谐振频率与空心磁性微球直径的关系。利用该示踪剂对低速流体流动进行了流动显示.提出了一种利用图像序列检测和计算二维场的新方法。该计算模型具有多通道运动检测器。实验结果表明，与单通道模型相比，该模型检测出的运动场更加可靠.该方法被应用于检测的血液流量。

项目成果

N.TAGAWA, Y.IKEDA, T.MORIYA: "On the Computation of 2-D Motion Field with Multi-resolution Images" Proc.of JTC-CSCC '94. D7-2-1 (1994)

N.TAGAWA、Y.IKEDA、T.MORIYA：“关于多分辨率图像的二维运动场计算”Proc.of JTC-CSCC 94。

N. TAGAWA, T. MORIYA: "Computing 2-D Motion Field with Multi-resolution Images and Cooperation of Gradient-based" IEICE Trans. Fundamentals. E78-A 掲載予定. (1995)

N. TAGAWA、T. MORIYA：“使用多分辨率图像和基于梯度的合作计算二维运动场”IEICE Trans 基础知识（1995 年）。

N. TAGAWA, Y. IKEDA, T. MORIYA: "On the Computation of 2-D Motion Field with Multi-resolution Images" Proc. of JTC-CSCC '94. D7-2-1 (1994)

N. TAGAWA、Y. IKEDA、T. MORIYA：“关于多分辨率图像的二维运动场计算”Proc。

N.TAGAWA, T.MORIYA: "Computing 2-D Motion Field with Multi-resolution Images and Cooperation of Gradient-based・・・" IEICE Trans.Fundamentals. E78-A (掲載予定). (1995)

N.TAGAWA、T.MORIYA：“使用多分辨率图像和基于梯度的合作计算二维运动场……”IEICE Trans.Fundamentals（即将出版）。