Comtrol mechamism of lipid metabolism helated genes by yatty acid

明确脂肪酸信号转导的正调控系统和负调控系统对改善人类健康具有重要意义。近年来，脂肪酸本身可能作为直接靶基因的配体信号，从而调控基因对脂质代谢及相关事件的转录调控。在本研究中，我们决定从细胞和分子方面系统地研究这些脂溶性维生素及其类似物对前脂肪细胞向脂肪细胞最终分化的影响。RA和1,25- oh2d3的作用被认为是由一种特定的核受体蛋白[视黄酸受体（RAR）；指定的α， β和γ亚型，维生素D受体（VDR）]，它们是配体依赖性转录调节因子的类固醇和甲状腺/类视黄醇受体超家族的成员。此外，我在大鼠小肠中发现了膜相关脂肪酸受体（mFAR）。mFAR作为长链脂肪酸的识别分子参与基因调控系统的信号转导。

It is important to the improvement of human health that the positive and negative regulatory systems for the signal transduction of fatty acids be well defined. Recently, fatty acids itself may act as a rigands signals to directly terget genes, and the results regulate the transcriptional control of genes on lipid metabolism and related events. In the present study, we have decided to systematically examine the effects of these fat soluble vitamins and their analogs on terminal differentiation from preadipocytes to adipocytes on the cellular and molecular aspects. The effects of RA and 1,25-OH2D3 are believed to be mediated by a specific nuclear receptor protein [retinoic acid receptor (RAR) ; designated ad subtypes alpha, beta and gamma, vitamin D receptor (VDR) ] which are members of the steroid and thyroid/retinoid receptor superfamily of ligand dependent transcriptional regulators. Furthermore, I revealed the membran asociated fatty acids receptor (mFAR) in the small intestine in rats. mFAR acts as a recognition molecule of long chain fatty acids on the signal transduction of regulatory systems for genes.