Analysis of regeneration mechamizm in brown adipose tissue relating commone direare

以肥胖者的身体状况为依据，出现高脂血症、糖尿病、高血压、动脉硬化等多种疾病状态(常见病)，并对其再次加重了如指掌。作为肥胖症的第一个因素，饲喂控制故障导致的能量过量摄入量降低，以及身体产热故障导致的能量消耗降低。本研究分析了控制棕色脂肪细胞功能的因素，以及作为人体产热器官的棕色脂肪组织功能障碍的产生机制，这是肥胖危机的关键。利用培养细胞对故障的改善进行了分析，提出了新分子营养学基础研究对肥胖预防和改善的指导性。在本研究中，饮食对人体产热器官--棕色脂肪组织的功能起到了增强作用。EVA…的建立通过饲养实验，利用大鼠、小鼠等实验动物，对天然产物衍生因子进行了更多的评价体系和提取。结果发现，实验动物棕色脂肪组织中含有丰富的不饱和脂肪酸，特别是多不饱和脂肪酸，能促进解偶联蛋白(UCP)这一功能蛋白和体热产生基因的表达。特别是，这种化合物存在于棕色脂肪组织中UCP亚型的UCP2mRNA中，说明它对肠道脂肪等似乎是常见疾病的诱发因素的内脏脂肪起到了储存控制的作用。因此，它对常见病非常有效。认为预防保健医学具有很强的社会意义，而本研究结果为阐明脂代谢紊乱疾病状态的发生机制和改善方法这一营养学领域的重要问题提供了新的视角的研究依据。较少

The body situation of the obesity is made to be a basis, and many disease states ( common disease) such as hyperlipidemia, diabetes mellitus, hypertension, arteriosclerosis appear, and to exacerbate again is knowing well. As a first factor of such obesity, the lowering of superfluous intake of the energy by the feeding control failure and energy consumption by the bodily heat production malfunction has been indicated. In this study, it was made that it analyzed the factor which controls brown fat cell function, while generation mechanism of the malfunction of brown fat tissue which is bodily heat production organ which holds the key of obesity crisis. Improvement of the malfunction is analyzed using culture cell, and presents the directivity of new molecule nutritional basic research for obesity prevention and improvement to be a purpose. In this study, the dietary which does enhancement of the function of brown fat tissue which is the bodily heat production organ. Establishment of eva … More luation system of natural product derived factor and retrieval were carried out using laboratory animal such as rat and mouse by the feeding experiment. As the result, fish oil component which abundantly contained the unsaturated fatty acid, especially polyunsaturated fatty acid, as a dietary factor which does enhancement of the expression of proteins of uncoupling protein (UCP) which is functional proteins and genes of the bodily heat production of laboratory animal brown fat tissue were found. Especially, this chemical compound are inside UCP2mRNA of the UCP subtype in the brown fat tissue It was clarified that it brought about the effect of storage control of offal fat such as the intestinal fat which seems to be generating factor of the common disease. And as the result, it is very effective for the common disease. It is considered that there is very much the social meaning on the preventive and healthy medicine, while the result of this study brings about the research basis from the new viewpoint for the elucidation of generation mechanism and improvement method of disease state with disorder of lipid metabolism for being an important problem in the nutrition science region. Less