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Analysis of regeneration mechamizm in brown adipose tissue relating commone direare

与普通可怕的棕色脂肪组织再生机制分析

基本信息

批准号：
09660136
负责人：
KAWADA Teruo
金额：
$ 2.11万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660136/
关键词：
adipose tissue obesity brown adipose tissue gene exphession Commone diseare Syndhme fish oil abdominal fat 遺伝子発現

项目摘要

The body situation of the obesity is made to be a basis, and many disease states ( common disease) such as hyperlipidemia, diabetes mellitus, hypertension, arteriosclerosis appear, and to exacerbate again is knowing well. As a first factor of such obesity, the lowering of superfluous intake of the energy by the feeding control failure and energy consumption by the bodily heat production malfunction has been indicated. In this study, it was made that it analyzed the factor which controls brown fat cell function, while generation mechanism of the malfunction of brown fat tissue which is bodily heat production organ which holds the key of obesity crisis. Improvement of the malfunction is analyzed using culture cell, and presents the directivity of new molecule nutritional basic research for obesity prevention and improvement to be a purpose. In this study, the dietary which does enhancement of the function of brown fat tissue which is the bodily heat production organ. Establishment of eva … More luation system of natural product derived factor and retrieval were carried out using laboratory animal such as rat and mouse by the feeding experiment. As the result, fish oil component which abundantly contained the unsaturated fatty acid, especially polyunsaturated fatty acid, as a dietary factor which does enhancement of the expression of proteins of uncoupling protein (UCP) which is functional proteins and genes of the bodily heat production of laboratory animal brown fat tissue were found. Especially, this chemical compound are inside UCP2mRNA of the UCP subtype in the brown fat tissue It was clarified that it brought about the effect of storage control of offal fat such as the intestinal fat which seems to be generating factor of the common disease. And as the result, it is very effective for the common disease. It is considered that there is very much the social meaning on the preventive and healthy medicine, while the result of this study brings about the research basis from the new viewpoint for the elucidation of generation mechanism and improvement method of disease state with disorder of lipid metabolism for being an important problem in the nutrition science region. Less

以肥胖的身体状况为基础，出现了高脂血症、糖尿病、高血压、动脉硬化等多种疾病状态（常见病），并且再次恶化是众所周知的。作为这种肥胖症的第一个因素，已经指出了由进食控制故障引起的能量的过量摄入和由身体产热故障引起的能量消耗的降低。本研究分析了控制棕色脂肪细胞功能的因素，而棕色脂肪组织作为机体产热器官，其功能障碍的产生机制是肥胖危机的关键。利用培养细胞分析了肥胖症的改善，提出了以预防和改善肥胖为目的的新分子营养基础研究的方向。在本研究中，膳食中的棕色脂肪组织的功能，这是身体的产热器官的增强。伊娃的建立 ...更多信息以大鼠、小鼠为实验动物，通过饲养实验，建立了天然产物衍生因子的检测体系，并进行了检索。结果发现，富含不饱和脂肪酸，特别是多不饱和脂肪酸的鱼油组分作为膳食因子，其增强解偶联蛋白（UCP）的蛋白质的表达，解偶联蛋白是实验动物褐色脂肪组织的身体产热的功能蛋白质和基因。该化合物位于褐色脂肪组织中UCP亚型的UCP 2mRNA内。已阐明，它带来了对内脏脂肪如肠脂肪的储存控制的效果，该内脏脂肪似乎是常见疾病的产生因素。因此，它对常见疾病非常有效。认为预防保健医学具有很大的社会意义，而本研究结果为阐明脂代谢紊乱疾病状态的发生机制和改善方法提供了新的研究依据，是营养科学领域的重要课题。少