THE EFFECTS OF TRICHOTHECENE(T-2 TOXIN)IN THE INTESTINAL IMMUNITY AND THE SENSITIVITY TO LISTERIOSIS.

在第一年中，检测了二孢噻吩（T-2毒素）对免疫活性细胞的影响。中、高剂量T-2毒素短期染毒可引起小鼠体重下降，胸腺、脾脏和血液中T、B细胞数量减少。另一方面，低剂量长期暴露可引起肠道淋巴细胞中免疫活性细胞数量的变化。这一结果表明，即使是低剂量的T-2毒素暴露也有引起胃肠道感染的危险。中剂量T-2毒素暴露的小鼠虽然免疫活性细胞减少，但仍表现出对李斯特菌病的抵抗力。这些小鼠中TNF-α和INF-γ的产生比未治疗的小鼠增加。这一结果表明，短时间暴露于二孢噻吩可增强细胞因子的产生，从而诱导获得对二孢噻吩抗性。

In the first year, the effects of trichothecene(T-2 toxin)on the immunocompetent cells were examined. The short term-exposure with middle or high dose of T-2 toxin caused the decrease of weights and the number of T cells, B cells in thymus, spleen and blood. On the hand, the long term-exposure with low does induced the change of the population of the immunocompetent cells in the lympocytes in intestine. This result suggests that even the exposure with low does of T-2 toxin has the risk of the gastrointestinal infection.In the last year, the effects of T-2 toxin on the sensitivity to listeriosis were examined. The mice exposured with middle dose of T-2 toxin showed the resistance to listeriosis though those immunocompetent cells were decreased. The production of TNF-alpha and INF-gamma in those mice rised than in no treatment mice. This result indicated the short term-exposure with trichothecene enhances the production of cytokines and then induces the acquisition the resistance to listeriosis.