Amelioration of murine listeriosis in the absence of NK cells and NKT cells and the analysis of the influence of double-stranded RNA on anti-bacterial resistance

NK细胞和NKT细胞缺失条件下小鼠李斯特菌病的改善及双链RNA对抗菌耐药性的影响分析

• 批准号: 22590388
• 负责人: EMOTO Yoshiko
• 金额: $ 2.91万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590388/
• 关键词: リステリア; 細胞内寄生細菌; NK 細胞; 二本鎖 RNA; PolyI:C; NK細胞; 二本鎖RNA; ＮＫ細胞; インターフェロン-γ; ナチュラルキラー細胞; NKT細胞

NK1.1^+ cells have been considered to play a protective role in various bacterial infections by secreting IFN-・upon infection. Yet, we have obtained the first evidence that NK cells play a detrimental role in protection against intracellular bacteria, Listeria monocytogenes. In contrast, we also found that anti-listerial resistance was markedly enhanced by PolyI:C and that NK cells participate in this mechanism. Thus, because our findings clearly demonstrated the new role of NK cells in intracellular bacterial infection, we consider it likely that our study contributes to the development not only of bacteriology, but also of immunology.

NK 1.1 ^+细胞被认为在各种细菌感染中通过在感染时分泌IFN-·而发挥保护作用。然而，我们已经获得了第一个证据，即NK细胞在保护细胞内细菌单核细胞增多性李斯特菌中起着有害的作用。与此相反，我们还发现，PolyI：C显著增强了抗Escherial抵抗，NK细胞参与了这一机制。因此，由于我们的发现清楚地证明了NK细胞在细胞内细菌感染中的新作用，我们认为我们的研究不仅有助于细菌学的发展，而且有助于免疫学的发展。

项目成果

Amelioration of murine listeriosis in the absence of NK and NKT cells

在缺乏 NK 和 NKT 细胞的情况下改善小鼠李斯特菌病

• 发表时间: 2013
• 作者: Kaneko M.;Emoto Y.;Yoshizawa I.;Hurwitz R.;Brinkmann V.;Kafmann S.H.E.;Emoto M.
• 通讯作者: Emoto M.