Gold(I)-Catalyzed Chloroalkynylation of Alkynes via Chlorine Shift

该项目的目的是通过实验和量子化学计算研究金（I）催化的氯代乙炔与内炔的分子间和分子内加成反应。在分子间的情况下，预期内部炔的1，2-氯炔基化，其通过1，3-氯位移进行。在分子内的情况下，1，4-氯位移应导致氯代乙炔的1，2-加成，并伴随着亲核试剂的加成。这两种反应都是用于合成复杂分子的新的碳-碳键形成过程，其中起始材料的卤素原子没有被丢弃，而是保留在产物中。这具有的优点是，产物中的反应性卤化物可用于进一步的化学转化。

The aim of the project is the investigation of the gold(I)-catalyzed inter- and intramolecular addition of chloroacetylenes to internal alkynes by means of experiments and quantum chemical calculations. In the intermolecular case a 1,2-chloroalkynylation of the internal alkynes is expected, which proceeds via a 1,3-chlorine shift. In the intramolecular case a 1,4-chlorine shift should lead to the 1,2-addition of chloroacetylenes accompanied by the addition of a nucleophile. Both reactions are new carbon-carbon bond forming procedures for the synthesis of complex molecules, whereby the halogen atoms of the starting material are not discarded, but remain in the product. This has the advantage that the reactive halide in the product can be used for further chemical transformations.