Role of Helicobacter pylori in the pathogenesis of gastric mucosa : long-term folow-up study in H.pylori infected Japanese macaques.

点击翻译按钮获取中文摘要

To assess the pathogenic role of persisitent colonization with H.pylori, we investigated the extended serial course of H.pylori infection and the damage to the gastric mucosa caused by a 3-year infection.A cute gastritis induced by H.pylori using an experimental model established in our laboratory were compared with a non-infected control group for 3 years.Colonization by H.pylori, gastritis scores, volume of intracellular periodic acid-Schiff (PAS) -positive substances and the height of antral glands were investigated every 3 months for 3 years and compared with those of a control group.In the infected group, persistent colonization with H.pylori was demonstrated by culture and histological examinations.Gastritis scores were significantly higher than those of the control group, and the histological findings were quite similar to those of chronic active gastritis observed in humans.Simultaneously, significant decreases in the contents of PAS-positive substances and in the height of antral glands were also demonstrated in infected animals.In the present study, experimental data clearly showed a significant decrease in glandular height in the antral mucosa of infected animals with severe loss of glandular volume also.Gastric antrum cell proliferation was significantly increased in the infected animals.These reaults strongly suggest that persistent colonization with H.pylori progress atrophic gastritis as a possible mechanism for a causal role in the chain of events leading to gastric carcinoma.