Us-Japan collaborative cohort study on cardiovascular risk factor in childhood

自1991年以来，我们根据美日合作协议研究儿童心血管危险因素。1993年至1994年的研究费用由科研资助基金(C)提供。对象与方法：对德克萨斯州休斯敦市Izumo (I)和Woodland District (W)的学龄儿童进行每年一次的随访研究。身高、体重、皮肤皱痕、血压、血脂按照标准数据在9岁（I组96男/89女，W组44男/43女）、12岁（I组91男/89女，W组46男/49女）和15岁（I组187男/167女，W组44男/34女）时进行检测。比较分析9、12、15岁时的身高、体重、皮肤褶皱、血压及8、9、11、12、14、15岁时的血清总胆固醇水平。结果：W组各年龄组平均身高、体重均高于对照组。男性的平均三头肌皮肤褶皱没有显著差异，但在1组中，女性的三头肌皮肤褶皱更高。平均收缩压无差异，但平均舒张压在I组各年龄段男女均较低。在10/12年龄/性别特异性比较中，平均血清总胆固醇I较高。这10个差异（I减去W）的范围从+6.3到20.5 mg/dl，而其余2个差异（I的较低值）仅为6 mg/dl或更低。结论：I（日本）儿童血清总胆固醇水平高于W（美国）。需要对日本和美国儿童进行更详细的长期队列研究。

Introduction :We have studied cardiovascular risk factor in childhood based on the US-Japan collaborative protocol since 1991. Our research expenses from 1993 to 1994 were contributed by Grant-in-Aid for Scientific Research (C).Subjects and Methods :School children of Izumo (I) and Woodland District (W) of Houston, Texas were subjected to follow-up study once every year. Height, weight, skin folds, blood pressure and serum lipids were checked according to standard data at the age of 9 years (96 males/89 females for I and 44 males/43 females for W), 12 years (91 males/89 females for I and 46 males /49 females for W) and 15 years (187 males/167 females for I and 44 males/34 females for W). Data relating to height, weight, skin folds and blood pressure at 9,12 and 15 years, and serum total cholestreol level at 8-9,11-12 and 14-15 years, were analyzed comparatively.Results :The mean hieght and weight of the W group were higher at each age. There was no siginificant difference in the mean triceps skin fold for males, but it was higher for females in the I group. There was no diffeerence in the mean systolic pressure, however the mean diastolic pressure showed a low level in both sexes at each age of the I group. The mean serum total cholesterol was higher in I in 10/12 age/sex specific comparisons. These 10 differences (I minus W) ranged from +6.3 to 20.5 mg/dl, while the remaining 2 differences (lower values in I) were only 6 mg/dl or less.Conclusion :I (Japan) exceeds W (USA) in childhood serum total cholesterol level. Further datailed long term cohort studies will be needed in Japanese and American children.