The roles of HLA genes relevant to gene therapy for human melanoma.

HLA 基因与人类黑色素瘤基因治疗相关的作用。

• 批准号: 05670733
• 负责人: MUTO Masahiko
• 金额: $ 1.22万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670733/
• 关键词: Human melanoma; Disease susceptibility; HLA polymorphism; Gene therapy

It has not been clear whether HLA antigens are associated with malignant melanoma in Japan. Acral lentiginous melanoma (ALM) may occur in Japanese but is uncommon in Caucasians. In order to elucidate involvement of HLA genes relevant to development of melanoma, we performed an HLA population survey, by using peripheral blood lymphocytes obtained from 58 unrelated Japanese patients with melanoma (20 nodular melanoma (NM) , 20 ALM,9 superficial spreading melanoma, 4 lentigo maligna melanoma, 4 melanoma derived from the membrane and 1 metastatic melanoma) . The results showed that there was a strong association between melanoma and HLA-B13 (p<0.0001) and Cw6 (p<0.03) . In NM,the frequency of HLA-B13 was extremely high. An increased frequency of HLA-B51 was seen in ALM (9/20=45 (%) vs 15/120=13 (%) in normal control) . In contrast, its frequency in NM was extremely decreased (1/20=5 (%) ) . HLA-B61 was decreased in a total of the melanomas. Thus, HLA-linked immune response or immune suppression gene (s) appear to contribute to the susceptibility to human melanoma. There might be genetic differences between NM and ALM.

目前还不清楚HLA抗原是否与日本的恶性黑色素瘤有关。肢端黄斑性黑色素瘤（ALM）可能发生于日本人，但在白种人中并不常见。为了阐明HLA基因与黑色素瘤发展的关系，我们对58名日本黑色素瘤患者（20例结节性黑色素瘤，20例恶性黑色素瘤，9例浅表性扩散黑色素瘤，4例慢体恶性黑色素瘤，4例膜源性黑色素瘤和1例转移性黑色素瘤）的外周血淋巴细胞进行了HLA人群调查。结果显示，黑色素瘤与HLA-B13 （p<0.0001）和Cw6 （p<0.03）有很强的相关性。在NM中，HLA-B13的频率非常高。在ALM中发现HLA-B51的频率增加(9/20=45（%)，而正常对照组为15/120=13(%)）。相比之下，其在NM中的频率极低（1/20=5(%)）。HLA-B61在所有黑色素瘤中均降低。因此，hla相关的免疫反应或免疫抑制基因似乎与人类黑色素瘤的易感性有关。NM和ALM之间可能存在遗传差异。

项目成果

Masahiko Muto,et al.: "HLA-B13 is a melanogenesis-related molecule." J.Dermatol.Sci.8. 87- (1994)

Masahiko Muto 等人：“HLA-B13 是一种与黑色素生成相关的分子。”

Masahiko Muto,et al.: "HLA-B13 is a melanogenesis-related molecule." J.Dermatol.Sci.8. 87 (1994)

Masahiko Muto 等人：“HLA-B13 是一种与黑色素生成相关的分子。”

Muto, M., et al.: "Major histocompatibility complex class I-associated susceptibility to malignant melanoma." J.Invest.Dermatol.102. 579 (1994)

Muto, M. 等人：“主要组织相容性复合物 I 类相关的恶性黑色素瘤易感性。”

Masahiko Muto,et al.: "Major histocompatibility complex class I-associated susceptibility to malignant melanoma." J.Invest.Dermatol.102. 579 (1994)

Masahiko Muto 等人：“主要组织相容性复合体 I 类相关的恶性黑色素瘤易感性。”

Masahiko Muto,et al.: "Major histocompatibility complex class I-associated susceptibility to malignant melanoma." J.Invest.Dermatol. 102. 579- (1994)

Masahiko Muto 等人：“主要组织相容性复合体 I 类相关的恶性黑色素瘤易感性。”