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Anthropogenic change and disease susceptibility in poison frogs: identifying links with diet, skin alkaloids, and the microbiome

毒蛙的人为变化和疾病易感性：确定与饮食、皮肤生物碱和微生物组的联系

基本信息

批准号：
2882384
负责人：
金额：
--
依托单位：
Bangor University
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2882384
关键词：
Anthropogenic change disease susceptibility poison

项目摘要

Anthropogenic disturbance, coupled with climate change, is a leading cause of biodiversity loss. In Ecuador, approximately 97% of the Chocó biodiversity hotspot is now deforested, underscoring the need to understand and predict species' responses to Anthropogenic change. This project will interrogate behavioural and microbial responses in the diablito poison frog, Oophaga sylvatica as a test case to assess how species respond to disturbance and climate change.The composition of microbiomes can change rapidly across environments, and microbiomes can play an important role in disease resistance in their host species. Understanding links between environmental change and the microbiome is therefore an important step in understanding disease susceptibility under Anthropogenic change. Oophaga sylvatica is an ideal model to test links between Anthropogenic change, behaviour, and the microbiome on susceptibility to the fungal skin pathogen Batrachochytrium dendrobatidis (Bd): O. sylvatica sequester toxic alkaloids from arthropod prey and their skin alkaloids can display microbial inhibitory activity in vitro. Oophaga sylvatica's diet and skin alkaloid profile have also been shown to be impacted by anthropogenic change. We hypothesise that variation in diet and skin alkaloids is driven by microhabitat choice, and that microbiome composition will have knock-on effects on susceptibility to Bd.

人为干扰，加上气候变化，是生物多样性丧失的主要原因。在厄瓜多尔，约97%的乔科生物多样性热点现已被砍伐，这突显了了解和预测物种对人为变化的反应的必要性。这个项目将询问毒蛙的行为和微生物的反应，作为测试案例，以评估物种如何对干扰和气候变化做出反应。微生物群落的组成可以在不同环境中迅速变化，微生物群落在宿主物种的抗病能力中可以发挥重要作用。因此，了解环境变化和微生物组之间的联系是理解人为变化下疾病易感性的重要一步。金龟子是测试人为变化、行为和微生物群对真菌皮肤病原体树枝杆菌(Batrachochytrium endrobatidis，Bd)易感性的理想模型：金龟子从节肢动物猎物中分离出有毒生物碱，其皮肤生物碱在体外可以显示出微生物抑制活性。沙棘的饮食和皮肤生物碱分布也被证明受到人为变化的影响。我们假设，饮食和皮肤生物碱的变化是由微生境的选择驱动的，微生物群的组成将对Bd的易感性产生连锁效应。