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Studies on Pancreatic Diseases Using PET

使用 PET 研究胰腺疾病

基本信息

批准号：
05670758
负责人：
TAKAHASHI Hiromu
金额：
$ 1.34万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670758/
关键词：
Diagnosis of pancreatic diseases Positron emission tomography ^<18>F-deoxy glucose ^<11>C-methionine Mucin producing pancreatic cancer Methionine deprived amino acids transfusion メチオニン欠如アミノ酸輸液 18F-デオキシグルコース 11C-メチオニン

项目摘要

Using positron emission tomography (PET), tumor images and pancreas parenchyma images are available for cancer cells which physiologically require glucose and for pancreas parenchyma tissue highly accumulated with amino acids, by administrating 2-deoxy-2-[^<18>F] fluoro-D-glucose (F), and ^<11>C-L-methionine (M), respectively.We report the results obtained in our studies on pancreatic cancer using PET.28 patients with pancreatic cancer were studied by PET with M and/or F.Image analysis was successful in 22 cases out of 28 pancreatic cancer patients given PET examination. 4 cases showed negative images of tumor only by M-PET, 2 cases displayd positive images of tumor only by F-PET and by both M & F-PET the tumor was visualised as M-negative and F-positive, that is, as mirror images in 15 cases. The cases confirmed by PET diagnosis were 21/22 (sensitivity 95%). We succeeded in diagnosing 2 muncin producing pancreatic cancer cases before operation by PET.The M distribution in the pancreas and other tissue of rats under L-methionine-deprived amino acid treatement was studied. It was suggested that a better prepared and more skillful experiment using M uptake of the pancreas starved for methionine could developthe diverse clinial application to PET graphical analysis.Along with the various current diagnoses, PET using ^<11>C-L-methionine and/or 2-deoxy-2 [^<18>F] fluoro-D-glucose was useful for pancreatic cancer diagnosis.

使用正电子发射断层摄影术（PET），通过给予2-脱氧-2-[1-F]氟-D-葡萄糖（F）和1-C-L-甲硫氨酸（M），可以获得生理上需要葡萄糖的癌细胞和高度积累氨基酸的胰腺实质组织的肿瘤图像和胰腺实质图像<18><11>，本文报告了28例胰腺癌患者的PET研究结果。或F.在28例接受PET检查的胰腺癌患者中，22例图像分析成功。4例仅M-PET显像阴性，2例仅F-PET显像阳性，15例M-PET和F-PET显像均为M阴性和F阳性，即呈镜像。PET诊断符合率为21/22（敏感性95%）。本文应用PET技术成功地对2例胰腺癌患者进行了术前诊断，并对去L-蛋氨酸（L-methionine，LMT）治疗的大鼠胰腺及其它组织中M的分布进行了研究。沿着目前的各种诊断方法，用~（4C-L<11>）-蛋氨酸和/或2-脱氧-2 [~（4F<18>）]-氟-D-葡萄糖进行的PET对胰腺癌的诊断是有用的。