Studies on Pancreatic Diseases Using PET

使用正电子发射断层扫描（PET），通过分别给予2-脱氧-2-[^<18>F]氟-d -葡萄糖(F)和^<11> c - l -蛋氨酸(M)，肿瘤图像和胰腺实质图像可用于生理上需要葡萄糖的癌细胞和高度积累氨基酸的胰腺实质组织。我们报告使用PET对胰腺癌的研究结果，28例胰腺癌患者使用PET与M和/或f进行了研究，28例胰腺癌患者中有22例进行了PET检查，图像分析成功。仅M- pet显示肿瘤阴性4例，仅F-PET显示肿瘤阳性2例，M和F-PET同时显示肿瘤为M阴性和f阳性，即15例为镜像。PET确诊病例为21/22（敏感性95%）。我们成功地对2例胰恶性肿瘤进行了术前PET诊断。研究了l -蛋氨酸剥夺氨基酸处理大鼠胰腺及其他组织中M的分布。因此，通过对蛋氨酸饥饿胰腺的M摄取实验，可以在PET图像分析中有更广泛的临床应用。随着目前的各种诊断，使用^<11> c - l -蛋氨酸和/或2-脱氧-2 [^<18>F]氟-d -葡萄糖的PET对胰腺癌诊断是有用的。

Using positron emission tomography (PET), tumor images and pancreas parenchyma images are available for cancer cells which physiologically require glucose and for pancreas parenchyma tissue highly accumulated with amino acids, by administrating 2-deoxy-2-[^<18>F] fluoro-D-glucose (F), and ^<11>C-L-methionine (M), respectively.We report the results obtained in our studies on pancreatic cancer using PET.28 patients with pancreatic cancer were studied by PET with M and/or F.Image analysis was successful in 22 cases out of 28 pancreatic cancer patients given PET examination. 4 cases showed negative images of tumor only by M-PET, 2 cases displayd positive images of tumor only by F-PET and by both M & F-PET the tumor was visualised as M-negative and F-positive, that is, as mirror images in 15 cases. The cases confirmed by PET diagnosis were 21/22 (sensitivity 95%). We succeeded in diagnosing 2 muncin producing pancreatic cancer cases before operation by PET.The M distribution in the pancreas and other tissue of rats under L-methionine-deprived amino acid treatement was studied. It was suggested that a better prepared and more skillful experiment using M uptake of the pancreas starved for methionine could developthe diverse clinial application to PET graphical analysis.Along with the various current diagnoses, PET using ^<11>C-L-methionine and/or 2-deoxy-2 [^<18>F] fluoro-D-glucose was useful for pancreatic cancer diagnosis.