Studies on efficacy evaluation and prediction of side effect of cancer chemotherapy using positron CT.

葡萄糖需求是肿瘤细胞、myocardium和大脑的生理特征之一。^<18>FDG（2-脱氧-2-（^<18>F）荧光-D-葡萄糖），正标记的葡萄糖模拟物被捕获在肿瘤细胞中，像myocardium一样的葡萄糖，但被困在葡萄糖路径中。在此特性的基础上，<18>FDG被用作追踪器，用于检测阳性发射断层扫描（PET）中的癌症。我们报告了通过比较图像的变化获得的结果，其中使用PET进行了临床<18>构建，用于FDG化疗期间的当前有效性评估。总共有10名高级癌症患者进行了测试。跟随^ FDG的注射<18>，ECAT II以X-CT确定的初级或变位肿瘤进行序列发射扫描。We attempted quantification of ^<18>FDG concentration in tumors as follows ： DAR（Differential Absorption Ratio）=（PET count x calibration factor）/（injected dose/body weight）。在补充中，他们的变化是由治疗引起的 ... More were calculated and denoted as DAR-ratio（DAR at examination/ DAR at previous examination）。效率的类别，被日本癌症学会癌症治疗和扫描图像的变化的评估方法所发现，与DAR-Ratio比较良好。在10种情况下，现行方法的效率评估之间存在着显著的关系，这是由于^<18>FDG-PET成像的变化。如果注意到^ FDG在肿瘤中的量化表达式<18>的变化，则表示为DAR-Ratio，非应答者有超过1.0的DAR-Ratio，而应答者低于0.7。在这些价值观和有效性评估类别之间没有不确定性;这一方法不仅可以通过化学疗法来表达肿瘤的形态变化，但可以量化肿瘤的代谢变化。Analytic studies on tumor image by ^<18>FDG-PET seem to be promising for the evaluation of efficacy of cManagement chemotherapy。It was expermentally observed with rats that the ^<18>FDG uptake into the heart decreased 3 days after the adriamycin of THP-Adriamycin administration。类似的结果也出现在其他人类细胞系中：乳酸霉素或KRN 8602（开发下）。从临床上看，^<18>FDG-PET-Cardial图像的DAR在案件中与抗癌药物相比，与那些没有抗癌药物的情况相比。我们相信，结果将为未来的研究做出贡献，以检测反化学药物的心脏毒性的机制。Less（低）

Glucose demand is one of the physiological characteristics of tumor cells, the myocardium and the brain. ^<18>FDG(2-deoxy-2-(^<18>F)fluoro-D-glucose), positron-labelled glucose analog is taken in tumor cells and the myocardium like glucose but trapped in the glucolysis pathway. On the basis of this property ^<18>FDG was used as tracer for detecting cancer with positron emission tomography(PET).We report the results obtained by comparing the change of the image, which was clinically constructed using PET with ^<18>FDG during chemotherapy, to the current efficacy evaluation.A total of 10 advanced cancer patients were examined. Following the injection of ^<18>FDG, serial emission scans by ECAT II were performed on the primary or metastatic tumor as determined by X-CT. We attempted quantification of ^<18>FDG concentration in tumors as follows : DAR(Differential Absorption Ratio)=(PET count x calibration factor)/(injected dose/body weight). In addition, their changes caused by the treatment … More were calculated and denoted as DAR-ratio(DAR at examination/ DAR at previous examination). The categories of efficacy・obtained by the evaluation method of the Japan Society for Cancer Therapy and changes of the scanning images as well as DAR-ratio were compared. In 10 cases, there was a significant relationship between the efficacy evaluation by current method and that by the change of ^<18>FDG-PET imaging. With regard to the change of quantitative expression of ^<18>FDG uptake in the tumor, expressed as DAR-ratio, nonresponder had the DAR-ratio of over 1.0, while that of responder was under 0.7. No inconsistency was found between these values and the categories of efficacy evaluation by current method.This method not only expressed morphological change of tumors but can quantify metabolic change in tumor tissues by chemotherapy. Analytic studies on tumor image by ^<18>FDG-PET seem to be promising for the evaluation of efficacy of cancer chemotherapy.It was expermentally observed with rats that the ^<18>FDG uptake into the heart decreased 3 days after the adriamycin of THP-Adriamycin administration. The similar result was seen with other kinds of anthracyclines : aclacynomycin or KRN 8602(under development). Clinically, the DAR of ^<18>FDG-PET-Cardial Image was relatively low in the cases administered with anticancer drugs compared to those without anticancer drugs. We are convinced that the results will contribute to the future study to detect the mechanism that causes cardiotoxicity of anticancer drugs. Less