Diagnosis of acute rejection using anti ICAM-1 and amlanti LFA-1 auhbahy in rat pancreatic transplantation

在本研究中，研究了胰腺移植后胰液和胰腺移植物中ICAM-1和LFA-1的出现。通过胰液细胞学，胰腺移植排斥反应的诊断是淋巴细胞、淋巴细胞、单核细胞和巨噬细胞的增加。研究细胞中ICAM-1和LFA-1的出现模式可能有助于早期诊断急性排斥反应。然而，用大鼠进行胰腺移植很难获得可接受的结果。此外，在大鼠身上很难获得胰液。在我们的模型中，胰液通过一根小口径的管子排出体外，但大鼠经常切断管子。即使保存了试管，也无法获得足够的汁液。为了获得胰液，可能需要一个可置于皮下的端口。因此，我们未能对大鼠胰液中包含的细胞进行研究。这种类型的研究在人类胰腺移植中是可能的。

In the present study, the appearance of ICAM-1 and LFA-1 in the pancreatic juice and pancreatic grafts are investigated following pancreatic transplantation. By pancreatic juice cytology, pancreatic graft rejection is diagnosed by the increase of lympho blasts, lymphocytes, monocytes and macrophages. It may be useful to investigate the mode of appearance of ICAM-1 and LFA-1 in the cells included in the juice for diagnosing acute rejection in the early stage. However, pancreatic transplantation using rats is difficult to achieve acceptable results. Furthermore, it was found to be difficult to obtain pancreatic juice in rats. By our model, the pancreatic juice was exteriorized via a small caliber tube, but rats cut the tubes frequently. Even if the tubes were preserved, sufficient amount of juice could not be obtained. In order to obtain pancreatic juice, a port, which can be placed subcutaneously, may be necessary. Thus we failed in investigating the cells included in the pancreatic juice in the rats. This type of research may be possible in human pancreatic transplantation.