Research for imainmotherany by iron-chelation against hepatocellular carcinoma

铁螯合抗肝细胞癌的母乳研究

• 批准号: 18590515
• 负责人: KUBOTA Keiichi
• 金额: $ 1.68万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590515/
• 关键词: hepatocellular carcinoma; colon cancer; iron-chelation; interferonY; apoptosis; DFO; 鉄イオン

Interferon y (IFNy) exerts its effect by biding to the specific receptor. IFNy receptor comprise of R1 and R2 subunits. In normal cells and cancer cells, R1 is constitutively expressed, but R2 is usually downregulated. Downregulation of R2 results in the resistance of cancer cells to anti-neoplastic effect of IFNy. It is necessary to increase the expression of R2 in cancer cells, in order to increase the susceptibility to IFNy. Because it has been shown that iron-chelation increase the expression of R2 in T cell lymphoma, we tested the effect of the iron-chelation in hepatocellular carcinoma (in year of 2006) and colon cancer (in year 2007). In both cancer cells, iron-chelation effectively increased the expression of R2, and resulted in increased susceptibility of IFNy, including growth inhibition and apoptosis-induction. It is suggested that iron-chelation. Plus IFNy is promising new method to treat hepatocellular carcinoma and colon cancer.

干扰素(IFNy)通过与特定受体结合发挥作用。IFNy受体由R1和R2亚基组成。在正常细胞和癌细胞中，R1是结构性表达的，但R2通常是下调的。R2的下调导致癌细胞对IFNy的抗肿瘤作用产生耐药。为了增加肿瘤细胞对干扰素的敏感性，有必要增加R2在癌细胞中的表达。由于已有研究表明铁络合物可增加T细胞淋巴瘤中R2的表达，因此我们测试了铁络合物在肝细胞癌(2006年)和结肠癌(2007年)中的作用。在这两种癌细胞中，铁络合物有效地增加了R2的表达，并导致了对IFNy敏感性的增加，包括抑制生长和诱导凋亡。建议采用铁络合法。加用干扰素治疗肝细胞癌和结肠癌是一种很有前途的新方法。

项目成果

Deferoxamine enhances anti-proliferative effect of interferon-γ against hpatocellular carcinoma cells

去铁胺增强干扰素-γ对肝癌细胞的抗增殖作用

• 发表时间: 2007
• 期刊: Cancer Letters 248
• 作者: Toshie Okada;Tokihiko Sawada;Keiichi Kubota
• 通讯作者: Keiichi Kubota

Deferoxamine enhances anti-proliferative effect of interferon-gammma against hepatocellular carcinoma cells

去铁胺增强干扰素γ对肝癌细胞的抗增殖作用

• 发表时间: 2007
• 期刊: Cancer Letters 248
• 作者: Okada T;Sawada T;Kubota K
• 通讯作者: Kubota K

鉄イオン調節による大腸癌におけるIFN-γ応答性増強に関する研究

铁离子调节增强结直肠癌IFN-γ反应性的研究

• 发表时间: 2006
• 作者: 森 昭三;澤田 登起彦;岡田 としえ;窪田 敬一
• 通讯作者: 窪田 敬一

Anti-proliferative effect of interferon y is enhanced by iron chelation in colon cancer cell lines in vitro

体外结肠癌细胞系中铁螯合增强干扰素 y 的抗增殖作用

• 期刊: Hepato Gastroenterology (IN PRESS)
• 作者: Mori S;Sawada T;Okada T;Kubota;K
• 通讯作者: K

Anti-proliferative effect of interferon γ is enhanced by iron chelation in colon cancer cell lines in vitro

体外结肠癌细胞系中铁螯合增强干扰素 γ 的抗增殖作用

• 期刊: Hepato-Gastroenterology (印刷中)
• 作者: Shozo Mori;Tokihiko Sawada;Toshie Okada;Keuchi Kubota
• 通讯作者: Keuchi Kubota