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THE METABOLISM AND PRACTICAL APPLICATION OF UNSATURATED FATTY ACIDS IN GASTROENTEROLOGICAL SURGERY

不饱和脂肪酸在胃肠外科中的代谢及其实际应用

基本信息

批准号：
05671064
负责人：
UNSAMI Makoto
金额：
$ 1.47万
依托单位：
KOBE UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671064/
关键词：
poly unsaturated fatty acids (PUFA)n6 PUFA n3 PUFA hepatic regeneration acute lung injery acute necrotising pancreatitis 多価不飽和脂肪酸(PUFA)n6多価不飽和脂肪酸インドメサシン多価不飽和脂肪酸 ω-6系脂肪酸 ω-3系脂肪酸

项目摘要

Polyunsaturated fatty acids (PUFA) of n6 and n3 groups, which are not synthesized in animals, are important components for cell membranes and cellular function. Liver regeneration after partial requires various nutrition, but the importance of fatty acids has not been reported. PUFA level decreased after hepatectomy and oil-deficient chow (deficient in n6 and n3 PUFA) suppressed DNA synthesis and hepatic regeneration. Addition of n6 PUFA improbe the DNA synthesis and hepatic regeneration, but not n3 PUFA.The AA (one of the n6 PUFA) is converted to prostanoids (PGE2, PGF alpha etc.) by cyclooxygenase, which stimulate DNA synthesis, and can be inhibited by indomethacin. After administration of indomethacin, the DNA synthesis was restrained. So, n6 PUFA is necessary for DNA synthesis and hepatic regeneration.On the other hand, n3 PUFA improbe the acute lung injery, which was induced by the endotoxin, and the combination of MCT and n3 is effective to decrease inflamatory reaction of acute necrotising pancreatitis.More research is needed to determine the proper fat content, the most favorable ratio of n6 and n3 PUFA and the best source of fatty acids.

N6和n3类多不饱和脂肪酸(PUFA)是细胞膜和细胞功能的重要组成部分，不是在动物体内合成的。部分肝再生需要多种营养，但脂肪酸的重要性尚未见报道。肝切除后多不饱和脂肪酸水平下降，缺油饲料(缺乏n6和n3多不饱和脂肪酸)抑制DNA合成和肝再生。添加n6多不饱和脂肪酸可促进DNA合成和肝再生，但对n3多不饱和脂肪酸无影响。通过环氧合酶刺激DNA合成，并可被吲哚美辛抑制。给予吲哚美辛后，DNA合成受到抑制。因此，n6多不饱和脂肪酸是DNA合成和肝脏再生所必需的。另一方面，n3多不饱和脂肪酸可减轻内毒素所致的急性肺损伤，MCT和n3联合应用可有效减轻急性坏死性胰腺炎的炎症反应。确定合适的脂肪含量、n6和n3多不饱和脂肪酸的最佳比例和最佳脂肪酸来源有待进一步研究。