SOD activity and localization of SOD in colorectal cancer

SOD 活性及其在结直肠癌中的定位

• 批准号: 05671084
• 负责人: SATOMI Akira
• 金额: $ 1.28万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671084/
• 关键词: SOD activity; TBRS; DNA ploidy pattern; localization of SOD; SODの局在; Cu,Zn-SODの局在

The significance of superoxide dismutase (SOD) in colorectal cancer tissue was determined from the aspect of the antioxidant system. SOD activity and thiobarbitueic acid reactive substance were measured in tumor, in tissue ajacent to the tumor, and in normal regions, and the results were analyzed in terms of histo-pathological factors. DNA ploidy pattern and cell proliferation in cancer tissue were also measured. The secondly, immunohisto-chemical stain of Cu, Zn-SOD was examined in cancer tissue, and the relationship between localization of SOD and biological malignancy was also investigated.SOD activity in cancer tissue was higher than in the other two regions. SOD activity in cancer tissue increased with the progression of stage. Vanous invasion was the most significant factor influenceing SOD activity. The localization of SOD is not always connected with SOD activity, and it does not reflect the biological malignancy.The elucidation of the antioxidant system in cancer tissue can provide us with a better strategy for cancer treatment. The estimation of SOD in cancer in cancer and non cancer region is useful for a predictor of not only sensitivty but also normal cell injury by chemotherapy and radiation therapy.

从抗氧化系统的角度确定超氧化物歧化酶（SOD）在结直肠癌组织中的意义。检测肿瘤、肿瘤邻近组织和正常区域的SOD活性和硫代巴比妥酸反应物质，并根据组织病理学因素对结果进行分析。还测量了癌症组织中的 DNA 倍体模式和细胞增殖。其次，对癌组织中的Cu、Zn-SOD进行免疫组化染色，并探讨SOD定位与生物恶性程度的关系。癌组织中SOD活性高于其他两个区域。癌组织中SOD活性随分期进展而升高。静脉侵袭是影响SOD活性最显着的因素。 SOD的定位并不总是与SOD活性相关，并不能反映生物的恶性程度。阐明癌组织中的抗氧化系统可以为我们提供更好的癌症治疗策略。癌症和非癌症区域的癌症中 SOD 的估计不仅可用于预测敏感性，还可用于预测化学疗法和放射疗法造成的正常细胞损伤。

项目成果

Akira Satomi et al: "Significance of superoxide dismutase (SOD) in human colorectal cancer tissue ; Correlation with malignant intensity." J Gastroenterol. 30. 177-182 (1995)

Akira Satomi 等人：“超氧化物歧化酶 (SOD) 在人类结直肠癌组织中的意义；与恶性程度的相关性。”

Akira, Satomi. et al: "Significance of superoxide dismutase (SOD) in human colorectal cancer tissue; correlation with malignant intensity" Journal of Gastroenterology. 30. 177-182 (1995)

阿基拉、里美。

Akira Satomi et al: "Significance of superoxide dismutase (SOD) in human colorectal cancer tissue; Correlation with malignant intensity" Journal of Gastroenterology. 30. (1995)

Akira Satomi 等人：“超氧化物歧化酶 (SOD) 在人类结直肠癌组织中的意义；与恶性程度的相关性”胃肠病学杂志。