DEVELOPMENT OF AN OXYGENATOR WITH BUILT-IN HEMOCONCENTRATOR

开发内置血液浓缩器的制氧机

• 批准号: 05671140
• 负责人: NISHIDA Hiroshi
• 金额: $ 1.34万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671140/
• 关键词: membrane oxygenator; hemoconcentrator; hollow fiber; blood outside flow mode; 限外ろ過; 外部灌流型; 酸素化能

In order to simplify the extracorporeal blood circuit and to facilitate handling of cardiopulmonary bypass, we have combined a hollow fiber unit for gas exchange and that for hemofiltration in one component and developed a new membrane oxygenator with a function of hemoconcentrator. The cylindrical device is consisted of a hollow fiber for hemofiltration with another fiber for gas exchange provided outside. Both of them adopt the blood outside perfusion system, Blood flows from around the center core towards the hollow fiber around it, first hemoconcentrator and then oxygenator, in radial direction. By applying this flow mode, even distribution of blood flow to the entire fiber was realized and the performance of the device was improved. Oxygen transfer rate was 336 ml/min at a flow rate of 6 L/min, and ultrafiltration rate was 7 L/hour with a flow rate of 4 L/min with a hematocrit of 25%. Pressure drop of the whole unit was only 60 mmHg with a flow rate of 6 L/min. The combined structure of the two units has not caused any adverse effects. In conclusion, by combining an oxygenator and a hemoconcentrator, excellent and simplified hemoconcentration is made available as the blood outside flow mode is adopted.

为了简化体外循环血液回路，方便体外循环操作，我们将用于气体交换的中空纤维单元和用于血液滤过的中空纤维单元结合在一个组件中，并开发了具有血液浓缩器功能的新型膜式氧合器。该圆柱形装置由一根用于血液滤过的中空纤维和外部提供的另一根用于气体交换的纤维组成。两者均采用血液外灌流系统，血液从中心芯周围沿径向流向周围的中空纤维，先经血液浓缩器，再经氧合器。通过应用这种流动模式，实现了血流在整个纤维上的均匀分布，提高了装置的性能。在6 L/min的流速下，氧转移速率为336 ml/min，超滤速率为7 L/h，流速为4 L/min，红细胞压积为25%。整个装置的压降仅为60 mmHg，流量为6 L/min。两个装置的组合结构未造成任何不良影响。综上所述，氧合器和血液浓缩器的组合，由于采用血液外流模式，因此可获得良好且简化的血液浓缩。

项目成果

西田博: "限外ろ過機能を有する新しい膜型肺-"人工腎肺"の開発" 人工臓器. 23. 234-237 (1994)

Hiroshi Nishida：“具有超滤功能的新型膜肺的开发 - 人工肾肺” 人工器官。23. 234-237 (1994)

西田博: "血液濃縮能を有する膜型肺-人工腎肺-開発の現況とその展望および有用性について" 薬理と臨床. (投稿中). (1995)

Hiroshi Nishida：“具有血液浓缩能力的膜肺 - 人工肾肺 - 发展现状、前景和用途”药理学和临床实践（目前正在提交）（1995）。

Nishida Hiroshi: "Oxygenator with built-in hemoconcentrator A Sew Concept" Artificial Organs. 19(in press). (1995)

西田博 (Nishida Hiroshi)：“带有内置血液浓缩器的制氧器 A Sew Concept”人工器官。

西田博: "血液濃縮器内蔵膜型肺の開発" 人工臓器. 24(投稿中). (1995)

Hiroshi Nishida：“内置血液浓缩器的膜肺的开发”人工器官24（目前已提交）。

西田 博: "限外ろ過機能を有する新しい膜型肺-“人工腎肺"の開発" 人工臓器. 23. 234-237 (1994)

Hiroshi Nishida：“具有超滤功能的新型膜肺的开发 - 人工肾肺” 人工器官。23. 234-237 (1994)