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Studies on vaccine therapy for rheumatoid arthritis.

Studies on vaccine therapy for rheumatoid arthritis.
类风湿性关节炎疫苗治疗的研究。
批准号:
05671212
负责人:
INOUE Koji
金额:
$1.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1995

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中文摘要
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英文摘要
A type II collagen (CII) reactive T cell clone (JT1) was established by IL-2 stimulation. This reactivity to CII was shown to be MHC restricted. The CII reactivity of JT1 was suppressed by phermacological dose of estradiol. We therefore investigated the estrogen receptor (ER) expressing cells in rheumatoid synovium, and found that hyperplastic synovial lining cells are expressing ER.We subsequently examined the ER expression of the articular cartilage, and found the ER mRNA in chondrocytes. Numerous attempts to establish hybridomas of JT1 and Jurkat (human T cell leukemia cell line) has been unsuccessful because of unstable nature of hybridoma. We are planning to make DNA analysis of T cell receptor of JT1.
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会议论文
Toshio Ushiyama,Koji Inoue,et al.: "Expression of estrogen recepto related protein (p29) and estradiol binding in human arthritic synovium." Journal of Rheumatology. 22. 421-426 (1995)
Toshio Ushiyama、Koji Inoue 等人:“雌激素受体相关蛋白 (p29) 的表达和人关节炎滑膜中雌二醇的结合。”
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通讯作者:
Toshio Ushiyama et al.: "Expression of estrogen recepto related protein (p29) and estradiol binding in human arthritic synovium." Journal of Rheumatology. Vol 22. 421-426 (1955)
Toshio Ushiyama 等人:“雌激素受体相关蛋白 (p29) 的表达和人关节炎滑膜中雌二醇的结合。”
DOI: --
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通讯作者:
Toshio Ushiyama,Koji Inoue,Junichi Nishioka: "Expression of estrogen receptor-related protein (P29)and estradid binding in human arthritic synovium." The Journal of Rheumatology. 22(in press). (1995)
Toshio Ushiyama、Koji Inoue、Junichi Nishioka:“雌激素受体相关蛋白 (P29) 的表达和人关节炎滑膜中雌激素的结合。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Toshio Ushiyama et al.: "Expression of estrogen recepto related protein(P29)and estradiol binding in human arthritic synovium" Journal of Rheumatology. 22. 421-426 (1995)
Toshio Ushiyama 等人:“人关节炎滑膜中雌激素受体相关蛋白 (P29) 的表达和雌二醇结合”风湿病学杂志。
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Creep degradation assessment for creep-strength-enhanced ferritic steels by positron annihilation spectroscopy
  • 批准号:
    24760573
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.91万
  • 财政年份:
    2012
  • 负责人:
    INOUE Koji
  • 依托单位:
Mechanisms to detoxify hydrogen sulfide using special amino acids in deep-sea organisms
  • 批准号:
    22380107
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $12.73万
  • 财政年份:
    2010
  • 负责人:
    INOUE Koji
  • 依托单位:
Manycore Processors for On-chip Supercomputing
  • 批准号:
    21680005
  • 项目类别:
    Grant-in-Aid for Young Scientists (A)
  • 资助金额:
    $16.89万
  • 财政年份:
    2009
  • 负责人:
    INOUE Koji
  • 依托单位:
High-k gate dielectrics investigated by laser-assisted three dimensional atom probe tomography
  • 批准号:
    20760212
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.66万
  • 财政年份:
    2008
  • 负责人:
    INOUE Koji
  • 依托单位:
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data