Early detection of ovarian malignancy by color doppler sonography and serum manganese superoxide dismutase

彩色多普勒超声和血清锰超氧化物歧化酶早期发现卵巢恶性肿瘤

• 批准号: 05671345
• 负责人: ISHIKAWA Mutsuo
• 金额: $ 1.34万
• 依托单位: ASAHIKAWA MEDICAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671345/
• 关键词: ovarian malignacy; pulasatility index; CA 125; Mn-SOD

To evaluate the efficiency of color doppler uetrasonography as the predictor of malignant ovarian tumors and to compare the results with serum manganses superoxide dismutase (Mn-SOD) levels for predicting ovarian malignancy. There were a signifocant difference in pulsatility index (PI) value of ovarian vessel between benign and malignant tumors. The specificity of morphorogic findings and CA125 was lower than that of P1 measurement, but sensitivty was not different among the three methods. In addition, serum Mn-SOD level measurements showed high diagnostic value in malignant ovarian tumor patients. PI measurements by tranvaginal color doppler ultrasound combined with Mn-SOD levels could be an accurate and appropriate screaning method for ovarian tumors.

目的：评价彩色多普勒超声对卵巢恶性肿瘤的预测价值，并与血清锰超氧化物歧化酶(Mn-SOD)水平进行比较。卵巢血管搏动指数(PI)值在良、恶性肿瘤之间有显著差异。形态学检查和CA125检测的特异性低于P_1测定，但三种方法的敏感性无差异。此外，血清锰-超氧化物歧化酶水平测定对卵巢恶性肿瘤患者具有较高的诊断价值。经阴道彩色多普勒超声结合锰-超氧化物歧化酶测定PI可作为一种准确、适宜的卵巢肿瘤筛查方法。

项目成果

M.Ishikawa,et al: "Expression of Manganase Superoxide Dismutase in Ovarian Carcinoma" ANTICANCER RESEARCH. 13(5B). 1667-1670 (1993)

M.Ishikawa 等人：“卵巢癌中锰酶超氧化物歧化酶的表达”抗癌研究。

T.Nishida,et al: "Serum Manganese Superoxide Dismutase(Mn-SOD) and Histological Virulence of Ovarian Cancer" Asia-Oceania Journal of Obstetrics and Gyneaecology. 19(4). 427-431 (1993)

T.Nishida等：“血清锰超氧化物歧化酶（Mn-SOD）与卵巢癌的组织学毒力”亚洲-大洋洲妇产科杂志。

M.Ishikawa: "Protection from oxidative stress by superoxide dismutase in fertilization and early gestation" Japanese Journal of Clinical Ecology. 3(1). 36-39 (1994)

M.Ishikawa：“超氧化物歧化酶在受精和妊娠早期保护氧化应激”，日本临床生态学杂志。

T.Nishida, T.Sugiyama, A.Kataoka, M.Tashiro, M.Yakushiji, M.Ishikawa.: "Serum Manganese Superoxide Dismutase (Mn-SOD) and Histological Virulence of Ovarian Cancer" Asia-Oceania Journal of Obstetrics and Gynecology. 19 (4). 427-431 (1993)

T.Nishida、T.Sugiyama、A.Kataoka、M.Tashiro、M.Yakushiji、M.Ishikawa.：“血清锰超氧化物歧化酶（Mn-SOD）与卵巢癌的组织学毒力”亚洲大洋洲妇产科杂志

T.Nakata, K.Suzuki, J.Fujii, M.Ishikawa and N.Taniguchi: "Induction and Release of Manganses Superoxide Dismutase from Mitochondria of Human Umbilical Vein Endothelial Cells by Tumor Necrosis Factor-alpha and Interleukin-1alpha." Int.J.Cancer. 55. 646-650

T.Nakata、K.Suzuki、J.Fujii、M.Ishikawa 和 N.Taniguchi：“通过肿瘤坏死因子-α 和白介素-1α 诱导和释放人脐静脉内皮细胞线粒体中的锰超氧化物歧化酶。”