Influence of Vasodilators on the Cardiac Function following Hypothalamic Stimulation in Coronary Stenosis Cat.

血管扩张剂对冠状动脉狭窄患者下丘脑刺激后心脏功能的影响

• 批准号: 05671667
• 负责人: SHIBUTANI Tohru
• 金额: $ 1.34万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671667/
• 关键词: Ischemic heart disease; Coronary stenosis cat; Hypothalamus stimulation; Psychological stress; Cardiac function; Vasodilator

The aim of this study is to make a model of ishemic heart disease by constricting coronary artery, and to examine the change of cardiac function following hypothalamic stimulation and vasodilators administration. Coronary stenosis cats were made by constricting left anterior descending branch(LAD). For the evaluation of hemodynamics and cardiac function, following parameters were measured ; arterial blood pressure, heart rate, cardiac output, blood flow of LAD,dp/dt, oxygen tesion of cardiac muscle. Anterior hypothalamus was electrically stimulated to make the situation of psychological stress the same as during dental treatment. Blood pressure, heart rate, cardiac output, coronary blood flow, dp/dt were increased during hypothalamus stimulation and returned to the control value after the end of stimulation. Oxygen tension of cardiac muscle was not changed significantly. In coronary stenosis cats, the changes of these parameters following hypothalamus stimulation were smaller than in non-stenosis cats. This suggests that the contractility of cardiac muscle is decreased by constricting coronary artery, and reserve capasity of cardiac function for psychological stress is decreased. We are now investigating the influence of vasodilators, such as nitroglycerine and calsium channel blockers, on the hemodynamic changes and cardiac function following hypothalamus stimulation.

本研究旨在通过缩窄冠状动脉的方法制备缺血性心脏病模型，观察刺激下丘脑和应用扩血管药物对心功能的影响。结扎冠状动脉左前降分支（LAD）造成冠状动脉狭窄。测定动脉血压、心率、心输出量、左前降支血流量、dp/dt、心肌氧分压，评价血流动力学和心功能。电刺激下丘脑前部，使心理应激的情况与牙科治疗期间相同。血压、心率、心输出量、冠状动脉血流量、dp/dt在刺激下丘脑期间增加，刺激结束后恢复到对照值。心肌氧分压无明显变化。在冠状动脉狭窄的猫，这些参数的变化后，下丘脑刺激小于非狭窄猫。提示缩窄冠状动脉使心肌收缩力下降，心功能对心理应激的储备能力下降。我们正在研究血管扩张剂，如硝酸甘油和钙通道阻滞剂，对下丘脑刺激后血流动力学变化和心功能的影响。