Physiopsychological Studies on Animal Model of Hyperactive (Learning Disability) Children.

多动（学习障碍）儿童动物模型的生理心理学研究。

• 批准号: 06451015
• 负责人: IWASAKI Tsuneo
• 金额: $ 4.03万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06451015/
• 关键词: 6-hydroxydopamine; neonatal treatments; brain dopamine; hyperactivity; stimulant drugs; microdialysis; learning disabilities; rats; 新生仔期処置

Behavioral and biochemical characteristics were investigated in neonatal brain dopamine depleted rats, a possible animal model of hyperactive (learning disability) children. On days 2 and 4 after birth, each rat of F344/Du strain received bilateral intraventricular injections of 6-hydroxydopamine (70mug). The results are as follows.1. Hyperactivity occurs prominently during the developing (premature) age. 2. Marked learning deficits appears on some (one-way and shuttle) types of avoidance tasks, which might be brought from prominent rearing and jumping responses under stressful situation. 3. Appetitive maze learning is also deteriorated. 4. Rewarding effects to dopaminergic stimulants are not changed. 5. Tissue contents of brain dopamine profoundly decrease, but extracellular concentration of dopamine remains to be relatively high. These results suggest that neonatal dopamine depleted rats are a promising animal model of hyperactive children.

研究人员对新生脑多巴胺耗尽的大鼠（一种可能的多动（学习障碍）儿童动物模型）的行为和生化特征进行了研究。出生后第2天和第4天，F344/Du品系每只大鼠均接受双侧脑室内注射6-羟基多巴胺（70μg）。结果如下： 1．多动症在发育（早产）年龄期间尤为明显。 2.在某些（单向和穿梭）类型的回避任务上出现明显的学习缺陷，这可能是由于压力情况下突出的后立和跳跃反应造成的。 3.迷宫学习的食欲也变差。 4. 多巴胺能兴奋剂的奖励效果没有改变。 5.脑组织中多巴胺含量大幅下降，但细胞外多巴胺浓度仍较高。这些结果表明，新生多巴胺耗尽的大鼠是一种有前途的多动儿童动物模型。

项目成果

Takashi OKAUCHI and Tsuneo IWASAKI: "Measurement of brain monoamine transmitters in neonatal 6-hydroxydopamine treated rats" Tsukuba Psychological Research. 18. 29-35 (1996)

Takashi OKAUCHI 和 Tsuneo IWASAKI：“新生 6-羟基多巴胺治疗大鼠脑单胺递质的测量”筑波心理学研究。

Miki TAKASUNA and Tsuneo IWASAKI: "Acive and passive avoidance learning in rats neonatally treated with intraventricular 6-hydroxy dopamine." Behavioural Brain Research. 74. 119-126 (1996)

Miki TAKASUNA 和 Tsuneo IWASAKI：“用脑室内 6-羟基多巴胺治疗的新生大鼠的主动和被动回避学习。”

Miki TAKASUNA and Tsuneo IWASAKI: "Active and passive avoidance learning in rats neonatally treated with intraventricular 6-hydroxydopamine" Behavioral Brain Research. 74. 119-126 (1996)

Miki TAKASUNA 和 Tsuneo IWASAKI：“用脑室内 6-羟基多巴胺治疗的新生大鼠的主动和被动回避学习”行为脑研究。

岡内 隆,岩崎庸男: "新生仔期6-hydroxydopamine処置ラットにおける脳内モノアミン系伝達物質の測定" 筑波大学心理学研究. 18. 29-35 (1996)

Takashi Okauchi，Tsuneo Iwasaki：“新生 6-羟基多巴胺治疗大鼠脑单胺递质的测量”筑波大学心理研究 18. 29-35 (1996)。

岡内隆,岩崎庸男: "新生仔期6-hydroxydopamine処置ラットにおける脳内モノアミン系伝達物質の測定" 筑波大学心理学研究. 18. 29-35 (1996)

Takashi Okauchi，Tsuneo Iwasaki：“新生 6-羟基多巴胺治疗大鼠脑单胺递质的测量”筑波大学心理学研究 18. 29-35 (1996)。