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Biopsychological study on the role of striatum in learning behavior

纹状体在学习行为中作用的生物心理学研究

基本信息

批准号：
08610071
负责人：
IWASAKI Tsuneo
金额：
$ 1.34万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08610071/
关键词：
learning memory striatum acety1choline gamma-aminobutyric acid rat ニコチン

项目摘要

It is recently shown that the striatum (caudate-putamen) is associated with memory and learning processes. We have investigated in this study what neural circuit is concerned with performance of spatial memory tasks. Intrastriatal kainic acid administration producing neuronal cell death in the striatum caused severe deficits in radial arm maze and Morris water maze learning. On the other hand, intrastriatal injection of 6-hydroxydopamine, a selective catecholaminergic neurotoxin, did not have any clear disruptive effect on radial maze performance. These results suggest that neuronal cell bodies in the striatum are necessary for correct performance of these tasks while dopaminergic input into the striatum does not play an important role. We have further investigated whether learning deficits produced by intrastriatal kainic acid injection was ameliorated by systemic treatment of' agonists of gamma-aminobutyric acid (GABA) receptors and nicotinic acetyIcholine receptors. GABA-A receptor agonist significantly improved the radial maze performance in kainic acid-treated rats, but GABA-B receptor agonist did not. Nicotine, a nicotinic receptor agonist, did not have any effect on the performance. Results suggest that learning deficits in kainic acid-lesioned animals may partly come from the loss of striatal GABA neurons, and that a circuit containing GABA-A receptors in the brain plays an important role for the performance of radial maze task. The effect of muscarinic receptor agonist remains to be investigated in order to clarify the role of cholinergic receptors in the striatum.

最近的研究表明，纹状体（尾壳核）与记忆和学习过程有关。在这项研究中，我们调查了什么样的神经回路与空间记忆任务的执行有关。纹状体内红藻氨酸给药引起纹状体神经元细胞死亡，导致桡臂迷宫和Morris水迷宫学习严重不足。另一方面，纹状体内注射6-羟基多巴胺，一种选择性的儿茶酚胺能神经毒素，没有任何明确的破坏性影响径向迷宫的性能。这些结果表明，纹状体中的神经元细胞体是正确执行这些任务所必需的，而纹状体中的多巴胺能输入并不起重要作用。我们进一步研究了γ-氨基丁酸（GABA）受体和烟碱乙酰胆碱受体激动剂的全身治疗是否能改善纹状体内注射红藻氨酸引起的学习障碍。GABA-A受体激动剂显著改善红藻氨酸处理大鼠的径向迷宫行为，而GABA-B受体激动剂则无此作用。尼古丁是一种烟碱受体激动剂，对成绩没有任何影响。结果提示，红藻氨酸损伤动物的学习障碍可能部分来自纹状体GABA能神经元的丢失，脑内含有GABA-A受体的回路在径向迷宫任务的执行中起重要作用。毒蕈碱受体激动剂的作用仍有待研究，以澄清纹状体胆碱能受体的作用。