The comparative study of MR functional imaging and H_2^<15>O-PET

MR功能成像与H_2^<15>O-PET的对比研究

• 批准号: 06454322
• 负责人: NISHIKAWA Junichi
• 金额: $ 1.54万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454322/
• 关键词: MR functional imaging (fMRI); H_2^<15>O-PET; Visual stimulation; Visual association area; MR functional imaging (fMRI); 聴覚刺激; 手指運動刺激

The purpose of this research project is whether MR functional imaging (fMRI) can evaluate both primary nad association cortical areas of the stimulation, and can clarify the significance of this activated cortical area by comparing with established brain functional examination of H_2^<15>O-PET.Basic study was carrid out in 1994 and the early period of 1995. Basic study showed that the visual stimulation using the video of computer graphics was suitale for activating the large area of cortex, and EPI method was suitable as the pulse sequence of fMRI for evaluating the activated cortical area three dimensionally.The comparative study was carried out in 1995. Subject was 9 adults, each of them had the same visual stimulation during fMRI and H_2^<15>O-PET.Both studies were done within 2 weeks.The comparison of images of both studies revealed below ;1, fMRI activated not only the primary visual cortex but also visual association cortex.2, The extend of activated isual cortices by fMRI was almost the same as that of H_2^<15>O-PET.3, The comparison between the activated visual association areas by monoclonal video and by color video showed that the latter was usually larger than the former.1,2 revealed that fMRI can detect the activated visual cortical areas as almost the same extend as H_2^<15>O-PET.The difference in the activated visual cortex seen on 3 may repressent that this difference corresponds to the fourth visual area which engages in the color perception.

本研究的目的是探讨磁共振功能成像（MR functional imaging，fMRI）是否能同时评价刺激的初级和联合皮质区，并与已建立的H_2^ O-PET脑功能检查相比较，阐明该激活皮质区的意义<15>，本研究于1994年和1995年初进行。基础研究表明，利用计算机图形学视频的视觉刺激适合于激活大面积皮层，EPI方法适合作为fMRI的脉冲序列，用于三维评价激活的皮层区域，并于1995年进行了对比研究。受试者为9名成年人，均在2周内进行了fMRI和H_2^<15>O-PET检查，两次检查的图像比较表明：1、fMRI不仅激活了初级视皮层，而且激活了视联合皮层; 2、fMRI和H_2^ O-PET检查激活的视皮层范围基本相同<15>。单克隆视频和彩色视频激活的视觉联想区之间的比较表明，后者通常大于前者。结果表明，fMRI和H_2^ O-PET对视觉皮层激活区的探测范围基本相同<15>，而3上所见的视觉皮层激活区的差异可能与第四视觉区的差异有关。