Effect of Spinal Cord Ischemia on Spinal Cord Evoked Potetials in the Canine

在8只麻醉犬胸主动脉夹闭造成动脉缺血模型上，记录脊髓诱发电位(ESCP)和酸性神经脊髓电位(SCSP)。并对其波形和幅度进行了比较。实验结束48小时后，取T-1~S-5脊髓整块取出，进行病理组织学观察。在电生理检查中，在腰大水平记录到的ESCP的N_2波幅、N_3波幅和坐骨神经的ESCP波幅的恢复率与组织病理学损害和神经预后相关。组织病理学检查发现，脊髓的缺血性改变主要见于下胸段至腰椎膨大的较大部分，且其改变具有不同程度的差异性。腰椎管扩张者后角而非前角受损，因此有必要监测ESCP和坐骨神经ESCP的N3波幅。

In eight anesthetized canines that had arterial ischemia produced by crossclamping of thoracic aorta, evoked spinal cord potentials (ESCP) and aciatic nerve spinal cord potentials (sciatic ESCP) were recorded. And their waveforms and amplitudes were compared. Further, after 48-hour the completion of experiment, the spinal cord from T-1 to S-5 was removed en bloc and studied pathohistologically. In the electrophysiological findings, the recovery ratio of the N2 amplitude of the ESCP,the N3 amplitude of ESCP and the sciatic ESCP recorded at the level of intumescentia lumbaris was correlated with the histopathological damages and neurological outcome. Histopathologic examination of the cord revealed that ischemic changes were especially found at the greater portion from lower thoracic region to intumescentia lumbaris and their changes were differentiated each levels. And posterior horns were damaged rather than anterior horns at intumescentia lumbaris, therefore it is necessary to monitor the N3 amplitude of ESCP and the sciatic ESCP.