Effect of Spinal Cord Ischemia on Spinal Cord Evoked Potetials in the Canine

脊髓缺血对犬脊髓诱发电位的影响

• 批准号: 06454431
• 负责人: HUJIMOTO Yoshinori
• 金额: $ 3.52万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454431/
• 关键词: Aortic occlusion; Spinal cord ischemia; Paraplegia; Evoked spinal cord potential

In eight anesthetized canines that had arterial ischemia produced by crossclamping of thoracic aorta, evoked spinal cord potentials (ESCP) and aciatic nerve spinal cord potentials (sciatic ESCP) were recorded. And their waveforms and amplitudes were compared. Further, after 48-hour the completion of experiment, the spinal cord from T-1 to S-5 was removed en bloc and studied pathohistologically. In the electrophysiological findings, the recovery ratio of the N2 amplitude of the ESCP,the N3 amplitude of ESCP and the sciatic ESCP recorded at the level of intumescentia lumbaris was correlated with the histopathological damages and neurological outcome. Histopathologic examination of the cord revealed that ischemic changes were especially found at the greater portion from lower thoracic region to intumescentia lumbaris and their changes were differentiated each levels. And posterior horns were damaged rather than anterior horns at intumescentia lumbaris, therefore it is necessary to monitor the N3 amplitude of ESCP and the sciatic ESCP.

在8只麻醉犬上记录了脊髓诱发电位（ESCP）和坐骨神经脊髓电位（坐骨ESCP）。比较其波形和振幅。此外，实验完成48小时后，将T-1至S-5的脊髓整体切除并进行病理组织学研究。在电生理结果中，在腰膨大水平记录的ESCP的N2振幅、ESCP的N3振幅和坐骨ESCP的恢复率与组织病理学损害和神经结局相关。脊髓组织学检查显示，缺血性改变以下胸区至腰膨大部为多见，且各节段缺血性改变有差异。在腰膨大处，脊髓后角受损较前角严重，因此有必要监测ESCP和坐骨神经ESCP的N3波幅。

项目成果

Shin Tanaka: "Effect of Spinal Cord Ischemia on Spinal Cord Evoked Potentials in the Dog" The Journal of Electrodiagnosis of the Spinal Cord. Vol.17. 65-68 (1995)

Shin Tanaka：“脊髓缺血对狗脊髓诱发电位的影响”《脊髓电诊断杂志》。

田中信: "脊髄虚血が脊髄誘発電位に及ぼす影響について(第1報)" 脊髄電気診断学. 17. 65-68 (1995)

Shin Tanaka：“脊髓缺血对脊髓诱发电位的影响（第 1 次报告）”《脊髓电诊断》。17. 65-68 (1995)