Studies on the pathogenesis and the prevention of drug-induced gingival hyperplasia.

各种药物（尤其是钙拮抗剂）引起的牙龈增生是重要的牙周病之一，但其发病机制尚不清楚。本文研究了钙拮抗剂硝苯地平引起犬牙龈增生的发病机制及预防措施。在大约6个月的时间里，一组狗通过刮治和根面平整来预防任何牙周疾病，另一组狗通过感染菌斑来允许牙周疾病。在这些预处理后，两组犬均接受硝苯地平治疗约一年半。观察两组患者血浆硝苯地平浓度与菌斑控制率、探诊深度、牙齿松动度、骨丢失、牙龈炎症、牙龈增生程度的关系，并对牙龈增生的组织病理学进行研究，试图揭示各种细胞因子是否与牙龈增生有关。IL-1、TNF、IL-4和TGF-β等细胞因子和粘附分子（ICM-1、VCAM-1和ECAM-1）在药物性牙龈增生的发病机制中起着重要作用。

The gingival hyperplasia induced by various drugs (in especial Ca-antagonists) is one of the important and inveterate periodental disorders, but its pathogenesis is still unknown. The pathogenesis of gingival hyperplasia induced by Ca-antagonist (Nifedipine) and its possible prevention were studied in dogs. During about 6 months, one group of dogs was prevented any periodontal disorders by scaling and root planing and other group of dogs was permitted periodental diseases by infected plaque. After these pretreatment, both groups of dogs were treated with Nifedipine during about one and half years. The relation between the concentration of Nifedipine in plasma and plaque control record, probing depth, tooth mobility, bone loss, inflamation of gingiva, grade of gingival hyperplasia was examined in both groups.We are now studing on the histopathology of hyperplastic gingiva and attempting to reveal whether various cytokines (IL-1, TNF,IL-4, & TGF-beta) and adohesion molecules (ICM-1, VCAM-1 & ECAM-1) have play a part in the pathogenesis of drug-induced gingival hyperplasia or not.